摘要
目的:检测慢性阻塞性肺疾病(COPD)患者血浆8-异前列腺素F2α(8-iso-PGF2α)及血清C反应蛋白(CRP)水平的变化,探讨COPD的发病机制。方法:用酶联免疫法测定27例COPD急性加重期患者及20例健康对照者血浆8-iso-PGF2α及血清CRP水平。结果:COPD患者血浆8-iso-PGF2α及血清CRP的水平明显高于正常对照组,有统计学差异。结论:COPD患者存在炎症及氧化应激水平升高,并参与了COPD的发生发展过程。
Objective：To investigat the plasma 8-iso-prostaglandin F2a （8-iso-PGF2a）and the serum C- reactive protein（CRP）levels in patients with chronic obstructive pulmonary disease（COPD）,and also explore the pathogenesis of COPD. Methods：ELISA method was used to determine the plasma level of 8-iso-PGF2a and serum level of CRP in 27 patients with acute exacerbation of COPD and in 20 control subjects. Results：The plasma 8-iso-PGF2a and serum CRP levels in patients with COPD were higher than that in control subjects（P〈 0. 01）. Conclusion： Oxidative stress and inflammation were increased in COPD which may be involved in the pathogenesis of COPD.
出处
《河北北方学院学报（医学版）》
2009年第4期13-15,共3页
Journal of Hebei North University:Medical Edition
