摘要
选用β－环糊精制备了贝尼尔缓释剂。该制剂为细颗粒状悬浮液，颗粒大小为０．２～０．４μｍ，分布均匀，粘度小，流动性好，稳定性较好，便于肌肉注射。通过兔、牛体内的免疫学测定，证明该缓释剂的药物释放时间比对照水剂延长０．８～１倍。贝尼尔缓释剂对瑟氏泰勒虫感染的预防试验结果表明，按每公斤体重５ｍｇ的剂量一次肌注，无论对本地牛还是外地引进牛，在２个月的保护率均达１００％，染虫率仅为０．１％～１％，呈现一定水平的带虫现象，而对照贝尼尔水剂组的保护期仅为２０ｄ。在牛瑟氏泰勒虫病的早期（１０ｄ以内）使用该缓释剂进行治疗，治愈率可达１００％，区域试验结果也证明了这一点，但剂量要适当加大，按每公斤体重用药７～１０ｍｇ。
A kind of Berenil slow release agent was compounded by the use of β cyclodextrin. It is a granular suspended solid of 0.2 0.4 μm size with containing less mucosity and excellent fluidity, therefore is convenient for i.m. It was proved that when injected at dosage of 5 mg/kg, the protective ratio of 100% obtained, the efficient preventive period to be no less than 2 months, longer than that of Berenil water agent (20 days). Applied during the early stage of the disease, the healing ratio could reach 100%.
出处
《中国兽医学报》
CAS
CSCD
北大核心
1998年第4期367-369,共3页
Chinese Journal of Veterinary Science
基金
吉林省科委资助
关键词
贝尼尔缓释剂
牛病
瑟氏泰勒虫病
预防
治疗
β cyclodextrin
Berenil slow release agent
theileriosis sergenti disease
prevention
therapeutics
