摘要
目的观察舒洛地特联合厄贝沙坦治疗老年糖尿病肾病的临床疗效。方法选择糖尿病肾病患者65例,随机分为对照组和治疗组。对照组在常规治疗的基础上加用厄贝沙坦,治疗组在对照组的基础上加用舒洛地特,8周后测定2组病人空腹血糖(FBG)、24 h尿蛋白定量、血清光抑素C、三酰甘油(TG)、纤维蛋白原(FIB)的变化。结果治疗组与对照组光抑素C、24 h尿蛋白定量都有所下降,治疗组比对照组下降更为明显(P<0.05);而TG、FIB只有在治疗组有所下降,明显低于对照组(P<0.01)。结论舒洛地特联合厄贝沙坦可以更有效地改善老年糖尿病肾病患者的肾功能。
Objective To observe the effects of the combination therapy of sulodexide and irbesartan in elderly patients with diabetic nephropathy （DN）. Methods Sixty-five patients with DN were randomly divided into treatment group and control group. Two groups were routinely treated with general treatment for DN. The control group were treated with irbesartan, and the treatment group received the combination therapy of irbesartan and sulodexide, additionally. After 8 weeks, 24 h urin protein, cystatin C, triglyeeride （TG） and fibrinogen（FIB） were measured in two groups. Results Compared with the control group, the levels of 24 b urin protein, cystatin C ,TG and FIB were decreased （P 〈 0.05 or P 〈 0. 01 ）. Conclusions Sulodexide combined with irbesartan can improve renal function in elderly patients with DN.
出处
《实用老年医学》
CAS
2009年第4期276-278,共3页
Practical Geriatrics
