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p300/CBP与肺癌 被引量：5

p300/CBP and Lung Cancer
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摘要 细胞核内DNA绝大多数时间缠绕并结合在组蛋白上，储藏在高度压缩的染色质中，处于非激活状态。细胞如需要激活一些基因，转录因子则协同将相关基因（DNA片段）从组蛋白上解离下来。其中一组转录因子家族为组蛋白乙酰转移酶（histone acetyltransferases，HATs），根据结构和活性可将其分为5个大家族：
作者 王恩旺 杨小龙
机构地区 皖南医学院附属弋矶山医院胸心外科
出处 《中国肺癌杂志》 CAS 2009年第8期926-930,共5页 Chinese Journal of Lung Cancer
关键词 p300 组蛋白乙酰转移酶 CBP 转录因子家族 DNA片段 肺癌 细胞核内 激活状态
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献28

  • 1Bazan JF. An old HAT in human p300/CBP and yeast Rtt109. Cell Cycle, 2008, 7(12): 1884-1886.
  • 2Livengood JA, Scoggin ICE, Van OK, et al. P53 trancscriptional activity is mediated through the SRC-1 interacting Domain of CBP/p300. J Biol Chem, 2002, 277 (11): 9054-9061.
  • 3Zeng L, Zhang Q,Gerona-Navarro G, et al. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure, 2008, 16(4): 643-652.
  • 4Chan HM, La Thangue NB. p300/CBP proteins: HATs for transcriptional bridges and scaffolds.J Cell Sci, 2001, 114(Pt 13): 2363-2373.
  • 5White NR, Mulligan P, King PJ, et al. Sodium butyrate-mediated Sp3 acetylation represses human insulin-like growth factor binding protein-3 expression in intestinal epithelial cells. J Pediatr Gastroenterol Nutr, 2006, 42(2) 134-141.
  • 6Wang L, Tang Y, Cole PA, et al. Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Curr Opin Struct Biol, 2008, 18(6): 741-747.
  • 7Kuritara I, Shibata H, Suzuki T. Expression and regulation of nuclear receptor coactivators in glucocorticoid action. Mol Cell Endocrinol, 2002, 189(1-2): 181-189.
  • 8Huang SM, McCance DJ. Down regulation of the interleukin-8 promoter by human papilloma virus type 16 E6 and E7 through effects on CREB binding protein/p300 and P/CAF.J Virol, 2002, 76( 17): 8710-8721.
  • 9Li F, Macfarlan T, Pittman RN, et al. Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities. J Biol Chem, 2002, 277(47): 45004-45012.
  • 10Vander Kemp PA, Charbonnier JB, Audebert M, et al. Catalytic and DNA- binding properties of the human OggI DNA N-glycosylase/AP Iyase: biochemical expIoration of H270, Q315 and F319. Nucleic Acids Res, 2004, 32(2): 570-578.

二级参考文献21

共引文献12

同被引文献30

  • 1林福地,谢庆祥,张闽峰,孟家榕,郭以河.转录因子E2F-1在肺癌组织中表达的意义[J].肿瘤防治杂志,2003,10(12):1263-1264. 被引量：7
  • 2张先华,阎翠华,朱慧芳,王竹辉.P300与survivin在宫颈癌中的表达及相关性探讨[J].实用医学杂志,2007,23(6):830-832. 被引量：3
  • 3Eckner R, Ewen M E, Newsome D, et al. Molecular cloning andfumctional an analysis of the adenovirus E1A-associated 300-kD protein(p300) reveals protein with properties of a tran- scriptional adaptor[J]. Gene Dev, 1994,8(8):869-884.
  • 4Giles R H, Peters D J M, Breuning M H. Conjunetion dys- function: CBP/p300 in human disease[J]. Trends Genet, 1998, 14(5):178-183.
  • 5Yang X J, Ogryzko V V, Nishikawa J, et al. A p300/CBPas- sociated factor that competes with the adenoviral oneoprotein E1A[J]. Nature, 1996,382(6589):319-324.
  • 6Kalkhoven E. CBP and p300: HATs for diferent occasions[J]. Bioehem Pharmacol, 2004,68(6):1145-1155.
  • 7Bryan E J, Jokubaitis V J, Chamberain N L, et al. Mutation analysis of EP300 in colon,breast and ovarian carcinomas[J]. Int J Cancer, 2002,102(2):137-141.
  • 8Delvecchio M, Gaucher J, Aguilar-Gurrieri C, et al. Structure of the p300 catalytic core and implications for chromatin tar- geting and HAT regulation[J]. Nat Struct Mol Biol, 2013,20(9): 1040-1046.
  • 9Shigeno K, Yoshida H, Pan L, et al. Disease-related poten- tial of mutations in transcriptional eofactors CREB-binding protein and p300 in leukemias[J]. Cancer Lett, 2004,213(1): 11-20.
  • 10Gayther S A, Batley S J, Linger L, et al. Mutations truncat- ing the EP300 acetylase in human Cancers[J]. Nat Genet, 2000,24(3):300-303.

引证文献5

二级引证文献23

中国肺癌杂志
2009年 第8期

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