摘要
自发性蛛网膜下腔出血引发的迟发性脑缺血(DCI)反应严重影响患者预后,近年来受到神经科学工作者的重视。血管性血友病因子(vWF)是存在于血浆、内皮细胞和血小板颗粒的一种大分子糖蛋白,过去多见于出血性疾病的研究。现有研究表明,DCI的发生和vWF存在相关性,现就二者的研究近况进行综述。
SAH induced delayed cerebral ischemia （DCI） influences outcomes of sufferers seriously. Von willberand factor （vWF） is one kind of macromolecular glycoprotein presented in plasma,endothelial ceils and platelets,which was particularly prevalent in the study of hemorrhagic diseases. Increasing evidences have shown that there is relationship between vWF and DCI. The structure, function and metabolism of vWF are briefly introduced,and its expression, effects and mechanism in DCI are also reviewed in the paper.
出处
《实用医院临床杂志》
2009年第4期21-23,共3页
Practical Journal of Clinical Medicine
关键词
蛛网膜下腔出血
脑缺血
血管性血友病因子
Subarachnoid hemorrhage
Delayed cerebral iscehmia
Von willberand factor
