摘要
目的观察温心汤治疗慢性心力衰竭的临床疗效。方法将67例慢性心力衰竭患者随机分为2组,均给予西医常规治疗,治疗组同时服用温心汤,14 d为1个疗程,观察2组患者治疗前后中医证候积分、Lee氏心衰积分、NYHA心功能分级及血清醛固酮水平的变化。结果治疗组中医临床疗效总有效率为91%,对照组为82%;治疗后2组中医证候积分、血清醛固酮水平均不同程度降低,治疗组中医证候积分、血清醛固酮水平降低程度较对照组明显(P均<0.05)。治疗中未发现与试验药物有关的不良反应。结论温心汤对慢性心力衰竭有一定的临床疗效,且无明显毒副作用,其改善心功能的作用可能与其抑制过度激活的RASS系统,降低患者血清醛固酮水平有关。
Objective It is to observe the curative effects of Winxin decoction on chronic heart failure（CHD）. Methods 67 patients with CHF were randomly divided into 2 groups. Both the groups were treated with normal western medicine. The treatment group was given Wenxin decoction at the same time. The treatment courses both were 14 days. The changes of traditional Chinese medical syndrome scores, Lee＇s CHD scores, HYHA heart function degree and the level of serum aldosterone in both groups were observed before and after treatment. Results The total effective rate of clinical traditional Chinese medical effect was 91% in treatment group and 82 % in control group. Traditional Chinese medical syndrome scores and the level of serum aldosterone in both groups were decreased more or less, but the decreasing degree in treatment group was more obviously than that in control group （ P 〈 0.05）. No side effect induced by the experimental drugs was found during the treatment. Conclusion It is concluded that Wenxin decoction is effective and safe for the patients with CHF without obvious toxic and side-effect. This mechanism of improving heart function may be related to its inhibiting effect on over-activated RASS system and serum aldosterone.
出处
《现代中西医结合杂志》
CAS
2009年第25期3012-3014,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
温心汤
慢性心力衰竭
血清醛固酮
Wenxin decoction
chronic heart failure
serum aldosterone
