摘要
目的探讨乳腺癌前哨淋巴结(SLN)微转移与非前哨淋巴结(nSLN)转移的关系,并分析其影响因素。方法对86例乳腺癌患者采用美蓝染料法定位活检前哨淋巴结,并用HE和CK19免疫组化法检测微转移灶。结果本组SLN阳性检出率约80%,假阴性率7.4%(2/27);灵敏度89%(24/27);准确率96%(66/69)。CK19免疫组化法检测出微转移前哨淋巴结9例,共12枚。检出率为20%(9/45)。SLN微转移与nSLN的转移无明显相关(P=0.127,P>0.05),而发生微转移的前哨淋巴结的数量和微转移灶的大小与nSLN的转移有关。结论染料法定位SLN、CK19免疫组化法检测微转移灶简便可行,微转移的SLN数目≥2和微转移灶直径>1mm可能对nSLN的转移具有明显的提示作用。
Objective To explore the relation between micrometastatic of SLN and metastatic of nSLN in patients with breast cancer and to analyze its influencing factors. Methods Methylene blue dye was used in 86 patients with breast cancer which SLNB was performed on . And then CK19 was used to detected micrometastatie in SLN with immunohistochemistry method. Results There were 17 patients failed to be found out SLN. A total of 149 SLN were indentified in 69 patients. The identification rate of SLN was 80% （69/86）. The false negative rate was 7.4 % （ 2/27） . The sensitivity was 89 % （24/27）. Mierometastatic was detected in 12 SLN of 9 cases and Positive rate was 20%. No significant relation was found between micrometastatic of SLN and metastatic of nSLN （P = 0. 127, P 〉 0.05）, whereas the amount of SLN with micrometastatic and diameter of micrometastatic focus 〉 l mm was respectively positive related to metastatic of nSLN. Conclusion The method of methylene blue dye as a tracer in SLNB was easy and viable. Micrometastatie of SLN was not relation to metastatic of nSLN. The amount of SLN with micrometastatic and the size of micrometastatic focus were useful cue to predict metastatic of nSLN.
出处
《宁夏医科大学学报》
2009年第4期432-434,F0002,共4页
Journal of Ningxia Medical University
