2Whitfield JF. The Solitary (primary) cilium-a mechanosensory toggle switch in bone and cartilage cells[ J]. Cell Signal,2008, 20 : 1019 - 1024.
3Tonna EA, Lampen NM. Electron microscopy of aging skeletal cells. 1. Centrioles and solitary cilia[ J]. J Gcrontol, 1972, 27 : 316 -324.
4Whitfield .IF. Primary cilium-is it an osteocyte' s strain-sensing flowmeter[ J ] ?J Cell Biochem,2003, 89 : 233 - 237.
5Xiao Z,Zhang S, Mahlios J, et al. Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression [ J ]. J Biol Chem, 2006, 281:30884 - 30895.
6Lu W, Shen X, Pavlova A,et al. Comparison of Pkdl-targeted mutants reveals that loss of polyeystin-1 causes cystogenesis and bone defects[ J ]. Hum Mol Genet,2001 , 10:2385 - 2396.
7Malone AM, Anderson CT, Tummala P, et al. Primary cilia mediate mechanosensing in bone cells by a carcium-independent mechanism[J]. Proc Natl Acad Sci USA,2007,104:13325 - 13330.
8Singla V, Rciter JF. The primary cilium as the cell' s antenna : signaling at a sensory organellc[ J ]. Science, 2006, 313:629 - 633.
9Xiao Z, Zhang S, Magenheimer BS,et al. Polycystinl-regulates skeletogcnesis through stimulation of the .steoblast-specific transcription factor RUNX2-II [ J ]. J Riol Chem, 2008, 283: 12624 - 12634.
10Guilak F, Alexopoulos LC, Upton MI., et ul. The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage[ J ]. Ann N Y Acad Sci,2006,1068:498 -512.
2[2]Pazour GJ.Intraflagellar transport and cilia-dependent renal disease:the ciliary hypothesis of polycystic kidney disease[J].J Am Soc Nephrol,2004,15(10):2528-2536.
3[3]Yoder BK,Hou X,Guay-Woodford LM.The polycystic kidney disease proteins,polycystin-1,polycystin-2,polaris,and cystin,are co-localized in renal cilia[J].J Am Soc Nephrol,2002,13(10):2508-2516.
4[4]Pazour GJ,San Agustin JT,Follit JA,et al.Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease[J].Curr Biol,2002,12(11):R378-R380.
5[5]Pazour GJ,Dickert BL,Vucica Y,et al.Chlamydomonas IFT88 and its mouse homologue,polycystic kidney disease gene tg737,are required for assembly of cilia and flagella[J].J Cell Biol,2000,151(3):709-778.
7[7]Nauli SM,Alenghat FJ,Luo Y,et al.Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells[J].Nat Genet,2003,33(2):129-137.
9[9]Masyuk AI,Masyuk TV,Splinter PL,et al.Cholangiocyte cilia detect changes in luminal fluid flow and transmit them into intracellular Ca2 + and cAMP signaling[J].Gastroenterology,2006,131 (3):911-920.
10[10]Smith LA,Bukanov NO,Husson H,et al.Development of polycystic kidney disease in juvenile cystic kidney mice:insights into pathogenesis,ciliary abnormalities,and common features with human disease[J].J Am Soc Nephrol,2006,17(10):2821-2831.
