摘要
目的寻找喘息样支气管炎患儿日后继发儿童哮喘的高危因素,为婴幼儿哮喘的早期干预提供依据。方法对119例喘息样支气管炎患儿进行问卷调查,并追踪随访12个月,根据随访结果,分析影响喘息样支气管炎日后继发哮喘的危险因素。结果成功随访108例,其中66例(61.11%)有明确喘息发作2次以上,可诊断为儿童哮喘,为哮喘组;42例(38.89%)有喘息样支气管炎患儿随访期未再有喘息发作,为未再发作组。对7种危险因素进行单因素分析发现:个人湿疹史、个人过敏史、母亲过敏史、父亲过敏史、母乳喂养不足4个月与喘息样支气管炎发展为婴幼儿哮喘有统计学意义。Logistic分析示:个人湿疹史(OR=2.820,95%CI:1.107～7.184,P<0.05)、个人过敏史(OR=2.756,95%CI:1.097～6.925,P<0.05)、母亲过敏史(OR=2.860,95%CI:1.070～7.642,P<0.05)、母乳不足4个月(OR=2.901,95%CI:1.176～7.155,P<0.05)是喘息样支气管炎发展为儿童哮喘的危险因素。结论喘息样支气管炎日后继发为婴幼儿哮喘的危险因素是患儿湿疹史和过敏史、母亲过敏史、母乳喂养不足4个月,患儿性别、父亲过敏史和二级亲属过敏史不是儿童哮喘的危险因素,婴幼儿哮喘为多种因素相互作用的复杂结果。
Objective To find the risk factors of infant asthma coming from asthmatic bronchitis and to provide the basic consideration for intervention in early asthma in children. Methods One hundred and nineteen infants with asthmatic bronchitis were followed up for 12 months in order to analyze the risk factors of child asthma coming from asthmatic bronchitis. Results 108 child patients were followed up successfully, of whom 66 （61.11% ） had two gasp episodes explicitly and were diagnosed as having child asthma, and were called asthma group, whereas 42 （38.89%） had no gasp episode again and were called asthmatic bronchitis group. Single factor analysis was conducted for seven risk factors. Individual＇s eczema history, individual＇s allergy history, mother＇s allergy history, father＇s allergy history, and breast milk feeding for less than 4 months were considered statistically significant for child asthma coming from asthmatic bronchitis （P 〈 0.05 ）. Logistic regression analysis discovered that individual＇s eczema history （OR = 2. 820,95 % CI ： 1. 107 - 7.184, P 〈 0.05 ）, individual＇ s allergic history （ OR = 2. 756,95% CI ： 1. 097 - 6. 925, P 〈 0.05 ）, mother＇s allergy history （ OR = 2. 860,95 % CI ： 1. 070 - 7. 642, P 〈 0.05 ）, and breast milk feeding less than 4 months （ OR = 2. 901,95 % CI： 1. 176 - 7. 155, P 〈 0.05 ） were risk factors of child asthma coming from asthmatic bronchitis. Conclusions The risk factors of child asthma coming from asthmatic bronchitis are individual＇s eczema history, individual＇s allergic history, mother＇s allergy history,and breast milk feeding less than 4 months. The child＇s sex, father＇s allergy history,and history of second degree rel- ative with asthma and allergy are not the risk factors of child asthma. So, child asthma is the result of many factors interaction. The asthmatic bronchitis with risk factors will possibly develop asthma, and should be highly noticed and prophylactic intervention meas- ures should be carried out in order to degrade the incidence of child asthma.
出处
《武警医学》
CAS
2009年第8期679-682,共4页
Medical Journal of the Chinese People's Armed Police Force
