摘要
目的:比较异丙酚和咪唑安定对低温体外循环(CPB)期间脑氧合的影响。方法:心内直视手术病人30例,随机分为:Ⅰ对照组,Ⅱ异丙酚组,Ⅲ咪唑安定组,每组10例。通过监测颈内静脉血氧饱和度(SjO_2)、动、颈内静脉血氧含量差(Da-vO_2)、脑氧摄取率(CEO_2)和动、颈内静脉血乳酸含量差(Da-vL),分析CPB期间脑氧合状况。结果:咪唑安定组降温时SjO_2明显升高、Da-vO_2和CEO_2明显减少(P<0.01);复温时SjO_2较前明显下降,但与CPB前比较无显著降低。异丙酚组在CPB中SjO_2、Da-vO_2和CEO_2无显著变化。三组病人Da-vL在CPB期间均未见明显增加。结论:体外循环时用异丙酚和咪唑安定加深麻醉,均能避免CPB期间脑氧合失衡。
Objective: To observe the effects of propofol and midazolam on cerebral oxygenation during CPB. Method:Thirty patients undergoing open heart surgery,were randomly divided into three groups (n=10):control group,midazolam group and propofol group. Jugular bulb blood oxygen saturation(SjO_2), arterial- venous oxygen content difference (Da-vO_2), cerebral oxygen extraction rate (CEO_2) and arterial-venous lactate difference (Da-vL) were measured at various times. Result:SjO_2 decreased significantly, Da-vO_2 and CEO_2 increased markedly during rewarming period in control and midazolam groups (P<0.01), but SjO_2 did not decline signficantly compared with baseline. In propofol group SjO_2 did not decline significantly during CPB (P>0.05). Da-vL did not change significantly during anesthesia in all patients (P>0.05). Conclusion:Administering propofol or midazolam is helpful in avoiding cerebral oxygenation imbalance during CPB.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1998年第7期392-394,共3页
Chinese Journal of Anesthesiology
关键词
心肺转流术
二异丙酚
脑氧合
咪唑安定
Cardiopulmonary bypass Propofol Midazolam Cerebral oxygenation
