摘要
目的:通过对心率变异性(HRV)功率谱分析,观察咪唑安定镇静时对HRV的影响。方法:随机选择ASA Ⅰ～Ⅱ级,在低位硬膜外阻滞下手术的成年病人15例。每隔3～5分钟静脉注射咪唑安定1.5mg,直至OAA/S评分值达到1分。观察不同OAA/S评分值时及OAA/S评分值达到1分后3分钟、5分钟、10分钟时HRV的变化。结果:HRV各成分随病人镇静程度加深明显降低,尤以LF和TP降低为明显。低频成分标准化值由33.5%降低至16.6%;高频成分标准化值由11.7%升至20.5%。LF/HF呈下降趋势。当病人镇静作用减退时HRV各值均逐渐恢复至基础水平。结论:咪唑安定对病人交感神经活动抑制显著,且有向迷走神经张力相对占优势方向转移的趋势。
Objective: To examine the effects of midazolam-induced sedation on heart rate variability (HRV). Method:Fifteen ASA Ⅰ- Ⅱ adult patients,undergoing elective surgery under lumbar epidural anesthesia were randomly selected. An intravenous bolus dose of midazolam(1.5mg) was administered every 3-5 minutes until patients' sedation levels assessed by observers assessment of alertness sedation(OAA/S) scale had scores of 1. Spectral analysis of HRV was performed at different OAA/S scores and at 3min,5min and 10min following OAA/S score of 1. Result:All frequency components of HRV were significantly reduced as patients' OAA/S scores decreased,especially low frequency (LF) and total power. Midazolam decreased normalized unit power of LF from 33.5%±8.9% to 16.65±9.6% and increased normalized unit power of high frequency(HF) from 11.7%±4.2% to 20.5%±26.5%. LF/HF ratio also reduced. Conclusion:Midazolam shiftes the balance of autonomic nervous activity toward the parasympathotonic.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1998年第7期388-391,共4页
Chinese Journal of Anesthesiology
