摘要
为研究环孢素Ａ（ＣｓＡ）降低血镁的作用及其机制，探讨ＣｓＡ诱导的低血镁是否与肾移植后高血压有关，以硫唑嘌呤（Ａｚａ）治疗组为对照组，以ＣｓＡ治疗血压正常组和ＣｓＡ治疗高血压组为研究组，检查了各组血镁浓度和镁排泄分数。结果：Ａｚａ组、ＣｓＡ血压正常组、ＣｓＡ高血压组的血镁浓度分别为０８２±０．０５ｍｍｏｌ／Ｌ、０７５±０．０６ｍｍｏｌ／Ｌ、０６６±００８ｍｍｏｌ／Ｌ，两两比较有显著性差异（Ｐ＜００５）；镁排泄分数分别为：６４％±２３％、７５％±３６％、８８％±３９％，两两比较有显著性差异（Ｐ＜００５）；低镁血症发生率分别为：６７％、５５０％、８１１％，两两比较有显著性差异（Ｐ＜００５）。结果提示：ＣｓＡ能引起肾移植患者血镁显著下降，这种低血镁可能是肾性镁丢失的结果，与肾移植后高血压相关。
To study the effects of Cyclosporine on magnesium metabolism in renal transplant patients and to determine whether CsAinduced hypomagnesemia was associated with post transplant hypertension,three patient groups were studied:15 Azatreated patients (groupl);20 CsAtreated patients with normal blood pressure (group2);32 CsAtreated patients with hypertension (group3).Serum magnesium and fractional excretion of magnesium were monitored.Serum magnesium in group 1,2,3 was 0.82±0.05mmol/L,0.75±0.06mmol/L and 0.66±0.08mmol/L,respectively (P<0.05);Fractional excretion of magnesium in group 1,2,3 was 6.4±2.3%,7.5±3.6% and 8.8±3.9%,respectively (P<0.05);6.7%,55.0%,81.1% of group 1,2,3 (P<0.05) respectively was noted to have hypomagnesemia.Our study indicates CsA may induce significant low serum magnesium in renal transplant patients,which is the result of urinary magnesium loss and is associated with post transplant hypertension.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1998年第7期426-428,共3页
Chinese Journal of Urology
关键词
环孢素
肾移植
低镁血症
Cyclosporine Kidney Transplantation Magnesium
