摘要
目的 :观察中药益肾缓衰方对慢性肾功能衰竭 (chronicrenalfailure,CRF)进展的作用。方法 :46例CRF患者分为两组 ,A组 (自身对照组 ) 1 8例治疗分为两个阶段 ,第一阶段先以低蛋白饮食及控制高血压治疗 ,第二阶段加用益肾缓衰方治疗 ;B组 2 8例 ,治疗方案与A组第二阶段相同。以计算血清肌酐倒数 (dl/mg)与时间 (月 )的直线回归斜率的方法评估慢性肾功能衰竭的进展速度。结果 :A组第一阶段血清肌酐倒数与时间的直线回归斜率均数为 -0 .0 1 0 4± 0 0 0 2 1 ,A组第二阶段斜率均数为 -0 0 0 3 4± 0 0 0 1 8,两者比较有显著性差异 (P <0 0 5 ) ;B组斜率均数为 -0 0 0 47± 0 0 0 2 0 ,与A组第一阶段比较有显著性差异 (P <0 0 5 )。结论 :在低蛋白饮食和控制高血压的基础上加用中药益肾缓衰方 ,可使慢性肾功能衰竭进展速度明显延缓。
Objective: To investigate the effect of Yishen Huanshuai recipe (YSHSR) on the progression of chronic renal failure (CRF). Methods: Forty six patients with CRF were divided into two groups: group A (self controlled group, n=18), whose treatment was subdivided into two stages. During the first stage, the patients treated with low protein diet and controlling blood pressure, while in the second stage, YSHSR was given. Group B(n=28), whose treatment plan was similar with that of group A in second stage. The rate of progression of CRF was estimated by slope of the creatinine reciporcal (dl/mg) with time (month). Results: Mean slope of the creatinine reciprocal with time from the group A during the first stage was -0.0104±0.0021, while during the second stage, it was -0.0034±0.0018. There was significant difference between them (P<0 05). Mean slope from the group B was -0.0047±0.0020. There was also significant differece between that from the group B and that from the group A during the first stage (P<0 05). Conclusions: Low protein and controlling blood pressure plus YSHSR therapy could markedly retard the rate of progression of CRF.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1998年第7期402-404,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
慢性
肾功能衰竭
益肾缓衰方
中医药疗法
Chronic renal failure, Yishen Huanshuai recipe, estimating progression of chronic renal failure
