摘要
目的:探讨血栓性血小板减少性紫癜(TTP)的病因、临床特点和治疗效果,以加深对该病的认识。方法:对15例TTP的类型、临床表现、治疗及预后进行回顾性分析。结果:15例中女性9例。原发性TTP10例,继发性TTP5例;5例继发性TTP中,感染所致2例,自身免疫性疾病1例,药物1例,妊娠1例。15例患者均为急性起病。临床主要表现为血小板减少、微血管病性溶血性贫血、神经精神障碍、发热及肾脏损害。5例继发性TTP患者以血浆置换(PE)和病因治疗为主,均治愈。10例原发性TTP采用以血浆置换为主的综合治疗,6例治愈,1例复发,3例死亡。结论:TTP的治疗应强调PE和输注新鲜冰冻血浆的重要性。
Objective： To investigate the pathogenisis, clinical characteristic and therapeutic response of thrombotic thrombocytopenic purpura （TTP）. Methods： Clinical manifestations, treatment and prognosis of 15 cases with TTP were analyzed retrospectively. Results： Nine of 15 cases were female. 10 cases were idiopathic TFP and 5 were secondary. The secondary TTP were caused by infection （2 cases）, autoimmune disease （1 case）, drug （1 case） and pregnancy （1 case）. All the patients with TTP developed and progressed rapidly. Clinical manifestations were characterized by thrombocytopenia, microangiopathic hemolytic anemia, neurologie abnormalities, fever and renal involvement. 5 secondary TI＇P patients were cured by plasma exchange （PE） and etilogical eradication. 10 idiopathic TTP patients were treated with PE and composite treatments, 6 patients were cured, 1 relapsed and the other 3 patients died. Conclusion： Treatment of TTP should emphasize the importance of PE and fresh frozen plasma infusion.
出处
《内科急危重症杂志》
2009年第4期202-204,共3页
Journal of Critical Care In Internal Medicine
