摘要
目的综合分析国内外可吸入大气颗粒物(PM_(10))短期暴露与人群死亡关系的流行病学资料,以获取大气PM_(10)污染与居民死亡的暴露-反应关系。方法在计算机联机检索文献和手工检索的基础上,对近十年来发表的相关研究文献采用meta分析的方法进行综合评价,并检验、校正可能存在的发表偏倚,从而准确、定量地确定PM_(10)污染与居民死亡的暴露-反应关系。结果建立了居民短期接触大气PM_(10)污染的暴露-反应关系,即在未考虑发表偏倚的情况下,大气中PM_(10)每增加100μg/m^3,居民死亡的相对危险度增加3.87%(95%CI:2.84%～5.02%),在校正了发表偏倚后大气中PM_(10)每增加100μg/m^3,死亡的相对危险度增加下降为1.41%(95%CI:0.30%～2.43%),与考虑偏倚前相比下降了63.6%。结论本研究建立的暴露-反应关系较早注意到发表偏倚的影响,具有一定的代表性与科学性,可用于大气颗粒物暴露健康危险度评价工作参考,为制定相关环境决策提供科学依据。
Objective： To do the epidemiological analysis based on the data of air inhalable particulate matter （PM10） and daily mortality, and to estimate the exposure -response relationship. Method：Based on the online search and manpower search in a library of relevant studies with the same endpoint, meta-analysis was used to do the com- prehensive assessment to determine the exposure-response relationship. Result：The exposure-response relationship between short-term exposure to ambient PM10 and the increased percentage of daily mortality was found, as the concentration of air PM10 increased by 100μg/m3, the dally mortality of residents increased by 3.87% （95% CI：2. 84% - 5. 02% ）when publication bias was not considered. But when we corrected the publication bias by filling the funnel plot, as the concentration of air PMI0 increased by 100μg/m3, the daily mortality of residents increased by 1.41% （95 % C1：0.30% -2.43% ）. Conclusion：The exposure-response relationship recommended in the present paper can be applied to the health risk assessment of air PM10 in various cities of China.
出处
《中国卫生监督杂志》
2009年第4期324-330,共7页
Chinese Journal of Health Inspection
