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血清中微小RNA作为肿瘤标记物的研究进展 被引量：4

Research advancement of small RNAs in serum as biomarkers of cancer
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摘要 血清中的微小RNA（miRNA）相对容易逃脱核糖核酸酶的消化，并且不易受酸碱度、温度及放置时间长短的影响，具有非常好的稳定性。肿瘤患者血清中发现了许多miRNA，一些已经被证实与肿瘤发生发展相关的miRNA在血清中高表达，并且对某些肿瘤具有高度敏感性及特异性，因此血清中的miRNA有望作为肿瘤标记物进行测定。 microRNA （miRNA） in serum are easy to escape from digestion of RNase relatively and when the PH, temperature and time vary, the miRNA don＇ t change in serum. Expression of many miRNA in serum of patients with tumor is higher than that in healthy persons. Some miRNA have sensitivity and specificity for tumors. So, miRNAs in serum can be hopefully regarded as a novel class of biomarkers for diagnosis of cancer.
作者 周素丽(综述) 郑智国(审校) 毛伟敏(审校)
机构地区 浙江中医药大学附属肿瘤医院肿瘤内科
出处 《国际肿瘤学杂志》 CAS 2009年第8期566-568,共3页 Journal of International Oncology
基金 基金项目：国家高技术研究发展计划资助项目（2007AA022165）
关键词 微RNAS 血清 肿瘤标记 生物学 MicroRNAs Serum Tumor markers, biological
分类号 R734.2 [医药卫生—肿瘤] R394 [医药卫生—医学遗传学]
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  • 1Duffy MJ. Clinical uses of tumor markers: a critical review. Crit Rev Clin Lab Sci 2001; 38:225-262.
  • 2Thomas CM, Sweep CG. Serum tumor markers: past, state of the art, and future, lnt J Biol Markers 2001; 16:73-86.
  • 3Duffy MJ. Role of tumor markers in patients with solid cancers: a critical review. Eur J lntern Med 2007; 18:175-184.
  • 4Roulston JE. Limitations of tumour markers in screening. Br J Surg 1990; 77:961-962.
  • 5Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.
  • 6Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6:857-866.
  • 7Chen C, Ridzon DA, Broomer A J, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005; 33:e179.
  • 8Tang F, Hajkova P, Barton SC, Lao K, Surani MA. MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res 2006; 34:e9.
  • 9Hafner M, Landgraf P, Ludwig J, et al. Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing. Methods 2008; 44:3-12.
  • 10Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006; 103:2257-2261.

共引文献1007

同被引文献49

  • 1He L,Thomson JM,Hemann MT,et al.A microRNA polycistron as a potential humanoncogene[J].Nature,2005,435(7043):828-833.
  • 2Wedel SA,Sparatore A,Soldato PD,et al.New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma[J].J Cell Mol Med,2008,12(6a):2457-2466.
  • 3Volinia S,Calin GA,Liu CG,et al.A microRNA expression signature of human solid tumors defines cancer gene targets[J].Proc Natl Acad Sci USA,2006,103(7):2257-2261.
  • 4Ambs S,Prueitt RL,Yi M,et al.Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer[J].Cancer Res,2008,68(15):6162-6170.
  • 5Sun R,Fu X,Li Y,et al.Global gene expression analysis reveals reduced abundance of putative microRNA targets in human prostate tumors[J].BMC Genomics,2009,10(1):93.
  • 6Porkka KP,Pfeiffer MJ,Waltering KK,et al.MicroRNA expression profiling in prostate cancer[J].Cancer Res,2007,67(13):6130-6135.
  • 7Saramaki OR,Porkka KP,Vessella RL,et al.Genetic aberrations in prostate cancer by microarray analysis[J].Int J Cancer,2006,119(6):1322-1329.
  • 8Ozen M,Creighton CJ,Ozdemir M,et al.Widespread deregulation of microRNA expression in human prostate cancer[J].Oncogene,2008,27(12):1788-1793.
  • 9Musiyenko A,Bitko V,Barik S.Ectopic expression of miR-126*,an intronic product of the vascular endothelial EGF-like 7 gene,regulates prostein translation and invasiveness of prostate cancer LNCaP cells[J].J Mol Med,2008,86(3):313-322.
  • 10Cimmino A,Calin GA,Fabbri M,et al.miR-15 and miR-16 induce apoptosis by targeting BCL2[J].Proc Natl Acad Sci USA,2005,102(39):13944-13949.

引证文献4

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国际肿瘤学杂志
2009年 第8期

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