摘要
目的:探讨不同疗程的三联疗法对溃疡愈合率和幽门螺杆菌(HP)的根除率是否有影响。方法:45例经胃镜确诊的十二指肠溃疡患者,经HP检查阳性。随机分成两组进行治疗,采用埃索美拉唑,阿莫西林及克拉霉素的三联疗法。A组为埃索美拉唑每日20mg,晨起空腹服用,服6周,阿莫西林1000mg,每日2次;克拉霉素500mg,每日2次,两者均服用1周;B组埃索美拉唑用法一样,而阿莫西林及克拉霉素的疗程为2周。两组均于治疗结束后4周复查胃镜,观察溃疡愈合率,并重复HP检查,观察HP根除率。结果:A组23例,溃疡愈合21例,愈合率91.3%,HP根除20例,HP根除率为86.9%;B组22例,溃疡愈合20例,愈合率90.9%,HP根除19例,HP根除率为86.4%。两者无论是溃疡愈合率还是HP根除率均没有明显差别,在统计学中的差异无显著意义。结论:以埃索美拉唑为基础的三联疗法中,阿莫西林及克拉霉素应用的时间不同对疗效无明显影响。
Objective： To compare the effects of different triple therapy regimens on healing rates of duodenal ulcer and HP infection. Methods： A total of 45 HP-positive patients with duodenal ulcer proven by gastroscope were divided into two groups randomly, Group A： twice daily treatment with esomeprazole 20 mg for six weeks, combined with amoxieillin 1 g and elarithromycin 500 mg for 1 week; Group B： twice daily treatment with esomeprazole 20 mg for six weeks, combined with amoxicillin 1 g and clarithromycin 500 mg for 2 weeks. The ulcer healing rate, HP detection were performed 4 weeks -after the completion of therapy. Results： 45 patients completed the trial. Ulcer healing rate and HP negative rate in Group A were 91.3%（21/23） and 86.9% （20/23）, respectively, and ulcer healing rate and HP negative rate in Group A were 90.9%（20/22） and 86.4%（19/ 20）.There was no significant difference between two groups （p〉0.05）. Conclusion： The curative effect of different triple therapy regimens based on esomeprazole is similar to each other, and the treatment course of antibiotic has no effect on healing efficacy in duodenal ulcer with HP positive.
出处
《安徽卫生职业技术学院学报》
2009年第4期26-26,28,共2页
Journal of Anhui Health Vocational & Technical College
关键词
十二指肠溃疡
幽门螺杆菌
三联疗法
疗程与疗效
Duodenal ulcer
Heliwbacter Pylor
TrrpleTherapy
Treatment wourse and Curative Effect
