期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MicroRNA与免疫反应及脓毒症 被引量：6

原文传递
导出
摘要 微小RNAs（MicroRNAs）又简称miRNAs，是一类长约21～25个核苷酸的小分子RNA，广泛存在于动物、植物、病毒和单个细胞生物体中。miRNAs存在于基因组的非编码区，属于非编码基因，不能编码蛋白。但它是一类重要的转录后调节基因，具有调节细胞增生、分化、凋亡等过程的功能，已经发现其参与肿瘤、血液性疾病、风湿性疾病和内分泌代谢等的调控。
作者 杜林林(综述) 马中富(审校)
机构地区 中山大学附属第一医院普内科
出处 《中国危重病急救医学》 CAS CSCD 北大核心 2009年第8期501-503,共3页 Chinese Critical Care Medicine
基金 基金项目：广东省科技计划项目（2004B30601002）
关键词 MICRORNA 免疫反应 脓毒症
分类号 R394.1 [医药卫生—医学遗传学] R392 [医药卫生—免疫学]
  • 相关文献

参考文献20

  • 1Pedersen I, David M. MieroRNAs in the immune response. Cytokine, 2008, 43 (3) :391-394.
  • 2Costinean S, Zanesi N, Pekarsky Y, et al. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E (mu)-miR 155 transgenic mice. Proc Natl Acad Sci USA, 2006, 103(18) : 7024-7029.
  • 3Rodriguez A, Vigorito E, Clare S,et al. Requirement of bic/mieroRNA-155 for normal immune function. Seienee, 2007, 316(5824) : 608-611.
  • 4Thai TH, Calado DP, Casola S, et al. Regulation of the germinal center response by microRNA-155. Science, 2007,316(5824) : 604-608.
  • 5O'Connell RM, Taganov KD, Boldin MP, et al, MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci USA, 2007,104(5) :1604-1609.
  • 6Tili E, Miehaille J J, Cimino A, et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/ TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol, 2007,179 (8) : 5082-5089.
  • 7Taganov KD, Boldin MP, Chang KJ, et al. NF-κB-dependent induction of mieroRNA miR-146, an inhibitor targeted to signaling protein of innate immune responses. Proe Natl Aead Sei USA,2006,103(33) :12481-12486.
  • 8Perry MM, Moschos SA,Williams AE, et al. Rapid changes in microRNA-146a expression negatively regulate the IL-1β-induced inflammatory response in human lung alveolar epithelial cells. J Immunol,2008,180(8) : 5689-5698.
  • 9张莹,姚咏明.调节性T细胞与脓毒症关系的研究进展[J].中国危重病急救医学,2006,18(11):695-697. 被引量：18
  • 10Shivdasani RA. MicroRNAs : regulators of gene expression and cell differentiation: Blood, 2706,108 (12): 3646-3653.

二级参考文献50

  • 1董月青,姚咏明.脓毒症中细胞免疫紊乱的机制[J].中国危重病急救医学,2004,16(10):636-638. 被引量：51
  • 2姚咏明,盛志勇.重视对脓毒症本质的探讨[J].中华急诊医学杂志,2005,14(3):185-186. 被引量：118
  • 3徐姗,姚咏明.树突状细胞及其与脓毒症关系的研究进展[J].中国危重病急救医学,2006,18(2):121-124. 被引量：5
  • 4Barth E,Fischer G,Schneider E M,et al.Differences in the expression of CD64 and CD14 (mCD14) on polymorphonuclear cells and on monocytes in patients with septic shock [J]. Cytokine, 2001,14: 299 -302.
  • 5Saccani S, Saccani S, Varesio, et al.Divergent effects of dithiocarbamates onAP-l-containing and AP - 1 - less NFAT sites [J]. Eur J Immunol, 1999,29:1194 - 1201.
  • 6Angus D C,Linde -Zwirble W T,Lidicker J,et al. Epidemiology of severe sepsis in the United States:analysis of incidence,outcome, and associated costs of care [J].Crit Care Med,2001,29:1303 - 1310.
  • 7Arbour N C,Lorenz E,Schutte B C,et al.TLR4 mutations are associated with endotoxin hyporesponsiveness in human [J].Nat Genet,2000,25:187 - 191.
  • 8Oberholzer A,Oberholzer C,Moldawer L L, et al. Sepsis syndromes: understanding the role of innate and acquired immunity [J]. Shock,2001,16:83 - 96.
  • 9Pellegrini J D,De A K,Kodys K,et al.Relationships between T lymphocyte apoptosis and anergy following trauma [J]. J Surg Res, 2000,88: 200 - 206.
  • 10Hotchkiss R S,Swanson P E,Freeman B D, et al. Apoptotic cell death in patients with sepsis, shock and multiple organ dysfunction[J]. Crit Care Med, 1999,27 :1230 - 1251.

共引文献65

同被引文献49

  • 1Jennifer Raisch,Arlette Darfeuille-Michaud,Hang Thi Thu Nguyen.Role of microRNAs in the immune system,inflammation and cancer[J].World Journal of Gastroenterology,2013,19(20):2985-2996. 被引量：18
  • 2李云婷.脓毒症发病机制与治疗进展[J].中国实用内科杂志,2006,26(9):1349-1352. 被引量：5
  • 3李志军,李银平,盖慧荣,薛永来,冯喜增.脓毒症大鼠肝组织基因表达的研究[J].中国危重病急救医学,2007,19(3):156-159. 被引量：10
  • 4熊霞辉,陈梅红.MicroRNA参与的调控网络[J].医学分子生物学杂志,2007,4(4):367-370. 被引量：5
  • 5Dombrovskiy VY,Martin AA,Sunderram J,et al. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States:a trend analysis from 1993 to 2003[J]. Crit Care Med, 2007, 35(5 ) : 1244-1250.
  • 6Miyara M,Sakaguchi S.Natural regulatory T cells:mechanisms of suppression[J]. Trends Mol Med, 2007,13 (3) : 108-116.
  • 7Levy MM, Fink MP, Marshall JC,et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference[J]. Crit Care Med, 2003,31 (4): 1250-1256.
  • 8Goya T,Abe M,Shimura H,et al.Characteristics of alveolar macrophages in experimental septic lung.J Leukoc Biol,1992,52:236-243.
  • 9Lomas-Neira J,Chung CS,Perl M,et al.Role of alveolar macrophage and migrating neutrophils in hemorrhage-induced priming for ALI subsequent to septic challenge.Am J Physiol Lung Cell Mol Physiol,2006,290:L51-58.
  • 10Lewis BP,Burge CB,Bartel DP.Conserved seed pairing,often flanked by adenosines,indicates that thousands of human genes are microRNA targets.Cell,2005,120:15-20.

引证文献6

二级引证文献27

中国危重病急救医学
2009年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部