摘要
目的:观察草分支杆菌F.U.36联合大剂量维生素C治疗小儿反复呼吸道感染(RRSI)临床疗效。方法:129例RRSI患儿,随机分为对照和治疗Ⅰ、治疗Ⅱ3个组。对照组39例给予青霉素及利巴韦林注射液iv,gtt,bid常规治疗,7～10d为1个疗程;治疗Ⅰ组45例,在上述常规治疗的基础上,同时给予草分枝杆菌F.U.36 1.72μg,深部i m,每周1次,1个月为1个疗程;治疗Ⅱ组45例,在治疗Ⅰ组的基础上,同时根据体质量大小分别给予维生素C3～5g.d-1,5d为1个疗程。观察3组疗效,并测定IgA、IgG、Ig M、CD3+、CD4+、CD8+、CD4+/CD8+的水平。结果:3组的总有效率分别为51.3%(20/39),84.4%(37/45),93.3%(42/45),3组比较差异有显著及极显著性(P<0.05或P<0.01)。治疗组治疗后,IgA、IgG、Ig M、CD3+、CD4+、CD8+、CD4+/CD8+值均明显增加(P<0.05或P<0.01)。结论:草分支杆菌F.U.36与大剂量维生素C联合应用防治小儿RRSI有明显疗效,能有效地改善免疫学指标,无明显不良反应。
OBJECTIVE To observe the therapeutic effect of Mycobacterium-phlei F. U. 36 injection and a large dose of vitmin C in treating children with reiterative respiratory tract infections. METHODS 129 children with reiterative respiratory tract infections（RRSI） were divided into three groups： the control group, NO. 1 treatment group and NO. 2 treatment group, the control group of 39 children received the conventional treatment with benzylpenicillin and ribavirin injection, iv, gtt, bid, 7- 10 d. 45 children of NO. 1 treatment group was furthermore treated with Mycobacterium phlei F. U. 36 injection 1 M1, im, once a week for 4 weeks than the control group. 45 children of NO. 2 treatment group was furthermore treated with vitamin C 3 - 5 g for 5d according to the body heavy than NO. 1 treatment group. The effect on three groups were observed and the IgA, IgG, IgM,CD3^＋ ,CD4^＋ ,CD8^＋ , CD4^＋/CD8^＋ level were measured before and after treatment. RESULTS The total effective rate of the 3 groups were 51.3% （20/39）, 84. 4% （37/45） and 93. 3% （42/45）, there were a significant difference and a very significant difference in the results of NO. 1 treatment group and NO. 2 treatment group compared with the control group after treatment, the level of IgA, IgG, IgM,CD3^＋ ,CD4^＋ ,CD8^＋ , CD4^＋/CD8^＋ in NO. 1 treatment group and NO. 2 treatment group were significant enhanced. CONCLUSION Mycobaeterium phlei F. U. 36 injection with a large dose of vitmin C is an effective agent in the treatment of RRSI without obvious adverse reaction.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第16期1370-1372,共3页
Chinese Journal of Hospital Pharmacy
