摘要
目的了解病理性瘢痕中氧化还原状态的变化。方法对正常皮肤、增生性瘢痕、瘢痕疙瘩组织中的氧化型与还原型谷胱甘肽（GSSG、GSH）、氧化型与还原型辅酶Ⅱ（NADP＋、NADPH）含量进行测定，计算还原型与氧化型的比值，分析氧化还原状态的变化。结果增生性瘢痕组和瘢痕疙瘩组组织中GSSG、GSH、NADP＋、NADPH的含量均高于正常皮肤组（P〈0．05），增生性瘢痕组和瘢痕疙瘩组之间各项指标差异均无统计学意义（P〉0．05），各组GSH／GSSG比值、NADPH／NADP＋比值差异均无统计学意义（P〉0．05）。结论组织微环境内氧化能力的提高，可能是病理性瘢痕发生机制中的一个重要环节；病理性瘢痕组织中，很有可能发生了氧化还原系统的代偿性再平衡。
Objective To investigate the change of the redox state of pathological scars. Methods Oxidized and reduced glutathione, coenzyme Ⅱ （ GSSG, GSH, NADP＋ , NADPH ） were selected for assay as the markers of redox state in the tissues of normal skin（ 15 cases） ,hypertrophic scar（20 cases） and keloid（20 cases）. Results Compared with normal skin tissue, the contents of GSSG, GSH, NADP ~ , NADPH were significantly higher in pathological scars （ P 〈 0. 05 ） , and the difference between hypertrophic scar and keloid was not significant （ P 〉 0.05 ）. There was no significant difference observed on the ratio of GSH/GSSG, NADPH/ NADP＊ in all the groups （ P 〉 0. 05 ）. Conclusion The increased oxidative capacity may play a role in pathogenesis of excessive growth of scar tissues. And the redox state may have reach equilibrium once more in the process of scar formation.
出处
《中国美容整形外科杂志》
CAS
2009年第8期501-503,共3页
Chinese Journal of Aesthetic and Plastic Surgery
基金
基金项目：国家自然科学基金资助项目（30672175）
四川省教育厅青年基金项目（07ZB124）
