摘要
AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.
AIM： To investigate the association between single nucleotide polymorphisms （SNPs） in the phosphatase and tensin homolog （PTEN） tumor suppressor gene and risk of colon cancer.METHODS： We utilized a population-based casecontrol study of incident colon cancer individuals （n= 421） and controls （n = 483） aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene.RESULTS： None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors （P 〉 0.05）. Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION： Our study does not support PTEN as a colon cancer susceptibility gene.
