摘要
目的探讨α-受体阻滞剂治疗前列腺增生不良反应。方法使用盐酸特拉唑嗪治疗161例患者,睡前口服1mg/d,2d后2mg/d,长期服用。盐酸坦索罗辛治疗165例患者,睡前口服0.2mg/d,长期口服。记录326例前列腺增生患者用药后不良反应。结果发生药物不良反应共34例,其中盐酸坦索罗辛13例,盐酸特拉唑嗪21例,口服药物3d内发生不良反应仅有特拉唑嗪19例。结论α-受体阻滞剂治疗前列腺增生症的不良反应,盐酸特拉唑嗪高于盐酸坦索罗辛(P<0.01)。老年人对降压药物的耐受性差,压力感受器反应障碍,故易产生体位性低血压。所以给予盐酸特拉唑嗪时,应从1mg用起,嘱睡前服用,还应告之可能出现的不良反应。如出现不良反应,应立即调整用药方案。
Objective To investigate the adverse reaction of α-recptor blockers in treatment of patients with benign prostatic hyperplasis （BPH）. Methods One hundred and sixty-one cases BPH were received Terazosin hydrochloride, taken 1 mg/d at bed-time, taken 2mg/d after 2 days to long time. 165 cases BPH were received Tamsulosin hydrochloride,taken 0.2mg/d at bed-time,taken 0.2mg/d long time. Adverse reaction were recorded for 326 cases BHP from From Jun. 2004 to Jun. 2008. Results Adverse reaction occurred in 34 patients. Among them,including observed in 21 patientes received Terazosin and 13 patients received Tamsulosin. There were 19 received Terazosin patients whose adverse reactibn occurred with in 3days only. Conclusion In the adverse reaction of a-receptor blockers in patients with BPH,Terazosin showed higher than Tamsulosin （P 〈 0.01 ）, The administration of terazosin should be initiated from the dose of ling and taken at bed-time,and the patients should be infromd of the possible adverse reactions of terazosin.because the elderly patients have poor tolerance to antihy pertensive agents and poor baroreceptor reflex which can easily in postural hypotension, If adverse reaction occurs,it is necessary to adjust medication plan in time.
出处
《中国现代医生》
2009年第24期63-64,共2页
China Modern Doctor
