摘要
研究了在ＣＨ３ＯＨ，Ｃ２Ｈ５ＯＨ，Ｈ２Ｏ３种溶剂体系中９９ｍＴｃＯ４－，乙酰苯肼（ＰｈＮＨＮＨＣＯＣＨ３，ＡＰＨ）、还原剂（Ｓｎ２＋、三苯基膦、三（间磺酸钠）苯基膦）与配体Ｅｔ２ＮＣＳ２Ｎａ的反应，以制备含［９９ｍＴｃＶＮ—Ｐｈ］３＋核的新配合物［ＴｃＶＣｌ（ＮＰｈ）（Ｅｔ２ＮＣＳ２）２］。用放射性纸层析、薄层色谱及放射性纸电泳对反应产物进行了检测，并测定了不同条件下产物在环己烷／水、正辛醇／水中的分配系数，得到了制备含［９９ｍＴｃＶＮ—Ｐｈ］３＋核的配合物的相关条件，还进一步研究了这种配合物的动物分布。结果是该配合物在正常小白鼠体内不稳定，心和脑的摄取率低。
Reactions of 99mTcO 4 -,acetylphenylhydrazine (PhNHNHCOCH 3),reducing agent (Sn2+,Triphenylphosphine,Tris(m sulfophenyl) phosphine) and ligand Et 2NCS 2Na in CH 3OH,C 2H 5OH and H 2O solvent systems were studied.The final new product 99mTc VCl(NPh)(Et 2NCS 2) 2 was characterized by paper chromatography,thin layer chromatography and paper electrophoresis,and also partition coefficients in cyclohexane/water and n octanol/water systems were measured.The biodistribution of this complex was also determined,showing that the complex does not accumulate in heart,nor brain.
出处
《北京大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
1998年第4期447-452,共6页
Acta Scientiarum Naturalium Universitatis Pekinensis
基金
国家自然基金
