摘要
红外光谱法研究胆总管结石，用定性及半定量法测定胆结石周边、各结晶环及核心的主要成分，有助于了解胆结石的详细结构，并探讨其结晶环的形成过程，随机取样２０例胆管结石，用ＫＢｒ压片法测定胆结石中各成分的含量，结果发现，黑色色素型结石２例，含中性胆红素钙络合物，磷酸钙及粘蛋白。棕色结石１８例（泥沙状结石６例，呈结晶环结石１２例），发现在结晶环结石中，只有５例含胆固醇，泥沙状结石平均含胆红素钙盐（８３．１±６．１）％，软脂酸钙盐（１５．７±７．９）％；棕色结石（含胆固醇）平均含胆红素钙盐（８１．１±６．５）％（周边），软脂酸钙盐（１８．６±６．６）％（周边）；胆红素钙盐（３４．１±１７．７）％（核心），软脂酸钙盐（３３．４±２．７）％（核心）；胆红素钙盐（５５．４±１２．４）％（结晶环），软脂酸钙盐（３４．４±１４．６１）％（结晶环）；棕色结石（不含胆固醇）平均含胆红素钙盐（７６．７±１０．９）％（周边）；软脂酸钙盐（２２．２±１２．６）％（周边）；胆红素钙盐（５８．５±１８．５）％（核心），软脂酸钙盐（４１．３±１８．５）％（核心）；胆红素钙盐（６４．２±２１．９）％（结晶环），软脂酸钙盐（３５．６±２１．９）％（?
Intraductal (common bile duct or intrahepatic duct) gallstones were rather prevalent in Asia and Taiwan.Comparing composition difference among central cores,rims and peripheries is help full to determine etiology in the process of stone nidation.Twenty sets of intraductal stones,including black pigment stone (n=2) and brown pigment stones (n=18),were quantitated by Infrared Spectroscopy.In brown pigment stones,12 sets of stones presented rim structure (rim stones) with cholesterol content in 5 cases but without cholesterol in 7 cases,and other 6 stones showed muddy appearance.Comparing compositions of brown pigment intraductal rim stones,the median content of calcium bilirubinate always presents peripheries>rim>central core with or without cholesterol content (core vs.peripheries,P<0.05).The distribution of calcium palmitate shows central core>rim>peripheries in rim stones without cholesterol (core vs.peripheries,P<0.05),or in rim stones with cholesterol (core vs.peripheries P>0.05).The median cholesterol content in rim stones with cholesterol content showed central core>rim without significance (P>0.05).The same significant difference of calcium bilirubinate and palmitate contents also present between central core of rim stones and muddy stones (P<0.05).From brown pigment stones,central core contains a significantly larger amount of calcium palmitate representing bacterial infection as a major pathological factor in early nidation of stone formation.On the contrary,calcium bilirubinates always significant present in peripheries and rims of rim structure stones and muddy stones,representing bile stasis as a important factors during stone growth.
出处
《北京大学学报（自然科学版）》
CAS
CSCD
北大核心
1998年第4期415-423,共9页
Acta Scientiarum Naturalium Universitatis Pekinensis
关键词
红外光谱
胆结石
组成
胆红素钙络合物
胆固醇
FT IR
gallstone
composition
calcium bilirubinate complexes
cholesterol
