摘要
目的评价克痤隐酮凝胶分阶段细化用药治疗寻常痤疮的疗效和安全性。方法将60例轻、中度寻常痤疮患者，随机分为分阶段细化用药治疗组（A组）和固定常规用药治疗组（B组），A组根据个体情况每日外用克痤隐酮凝胶1～4次，每周复诊并拍摄照片观察疗效，以指导调整治疗剂量；B组固定常规用药，每日2次。治疗6～8周后观察各组皮损变化情况。结果A组和B组痤疮患者痊愈率分别为66．7％和36．7％，组间差异有统计学意义（P〈0．01）。A组治疗过程中仅有少数患者出现皮肤刺激症状，未见严重不良反应，但不良反应发生率高于B组。结论克痤隐酮凝胶分阶段细化用药治疗寻常痤疮疗效良好，合理地增加日用量剂量较固定常规用药组可提高痊愈率；且刺激性较低，患者皮肤对此药的耐受性较好。
Objective To evaluate the clinical efficacy and safety of Kecuo Yingtong gel with detailed treatment regimen for acne vulgaris by phase. Methods Sixty patients with acne vulgaris of mild to the severity were randomized to receive either detail by phase group （A） or conventional group （B）. Group A was treated with Keeuo Yingtong gel topically 1 to 4 times daily according to the severi- ty of the disease. Clinical responses were recorded and photographed weekly in group A, and treatment regimens were adjusted accordingly. Group B only was treated with Kecuo Yingtong gel 2 times daily for 6 to 8 weeks. Results It was shown that cure rates were 66.7% and 36.7% in the groups A and B, respectively. There was no statistical difference between the 2 groups （P〈0.05）. Only few patients had stimulating symptoms, and severe adverse effects had not been observed. However, inci dence of the side effects was higher in group A than group B. Conclusions Kecuo Yingtong gel has been proved to have an excellent response with detailed treatment by phase. Reasonably increasing the daily dosage could improve the cure rates. The cutaneous tolerability of the drug is generally good.
出处
《中华医学美学美容杂志》
2009年第4期223-225,共3页
Chinese Journal of Medical Aesthetics and Cosmetology
