摘要
目的探讨钙蛋白酶10（CAPN10）基因SNP43、SNP44位点及主要单倍型、单倍型组合与2型糖尿病（T2DM）的关联性。方法根据系统评价的原理和规范，检索PubMed及中文期刊数据库，纳入CAPN10基因与T2DM的病例对照研究。根据种族，采用分层Meta分析评估CAPNIO基因多态性与T2DM的关联性。同时评估发表偏倚。结果各种族与T2DM有关联的基因多态性分别是：蒙古人种，SNP43位点G等位基因OR=1．368（95％CI：1．155～1．620），G／G基因型OR=1．437（95％CI：1．186—1．741），111／221单倍型组合017=2．762（95％CI：1．287—5．927）；高加索人种，SNP44位点C等位基因OR=1．144（95％CI：1．023—1．278），111／111单倍型组合OR=1．291（95％CI：1．050-1．586）；混血人种，SNP44位点C等位基因OR=1．653（95％CI：1．025—2．665）。结论SNP43位点G等位基因、G／G基因型、111／221单倍型组合是蒙古人种的危险因素；SNP44位点C等位基因、111／111单倍型组合是高加索人种的危险因素；SNP44位点C等位基因是混血人种的危险因素。
Objective The purpose of this study was to approach the relation of SNP43, SNP44 locus, main haplotypes and haplotype combinations with type 2 diabetes mellitus （T2DM）. Methods According to the theory and principles of systematic review, data from case-control studies regarding the association between calpain-10 （CAPN10） gene and T2DM were derived through electronic search of PubMed and Chinese journals databases. To gain a more precise estimation of the relationship, a stratified Meta-analysis with four subgroups was performed according to the races. Publication bias was also assessed, Results The association with T2DM in different races was evaluated, In Mongoloid race, SNP43-G allele, G/G genotype and 111/221 haplotype combination showed notable association with T2DM with ORs（95%CI）as 1.368（1.155-1.620）, 1.437 （ 1.186-1.741 ） and 2.762 （1.287-5.927） respectively. In Caucasoid race, SNP44-C allele, 111 / 111 hapotype combination showed strong relationship with T2DM with ORs（95%CI）as 1.144 （1.023-1.278） , 1.291 （1.050-1.586） respectively. In Hybrid race, only one positive finding was obtained which was SNP44-C allele with OR （95% CI） as 1.653 （1.025-2.665）. Conclusion SNP43-G allele, G/G genotype, 111/221 were risk factors to Mongoloid race. And SNP-C allele, 111/ 111 haplotype combination were risk factors to Caucasoid race, and SNP44-C allele to Hybrid race.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2009年第8期850-856,共7页
Chinese Journal of Epidemiology
基金
国家“十一五”科技支撑项目（2006BAI02B08）（志谢：南京医科大学流行病与卫生统计学系周敏林硕士协助完成文献检索、数据整理与核查
美国加州大学洛杉矶分校公共卫生学院流行病学系SiminLiu教授提供详细数据
香港中文大学内科及药物治疗学系内分泌与糖尿病科室Maggie CY Ng博士、德国德累斯顿工业大学Carl Gustav Cams医学系PeterSchwarz教授提供相关科研成果及信息）
