摘要
为了观察骨巨细胞瘤刮除术后局部应用几丁糖阿霉素缓释药粒的疗效及全身反应，对４例骨巨细胞瘤刮除术后残腔应用４倍于常规静脉阿霉素用量的几丁糖阿霉素缓释药粒，检测术后１，２及５天血浆中阿霉素含量，以及术后１周、１个月及６个月的肝肾功能。结果表明，术后１，２及５天血浆中阿霉素含量分别为（１４３．０５±２７．５５）ｎｇ／ｍｌ、（５２．１７±１１．２８）ｎｇ／ｍｌ及（４．２５±３．０７）ｎｇ／ｍｌ，术后１周、１个月及６个月的肝肾功能均正常。随访７个月～１９个月，无局部复发、全身反应及Ｘ线片复发表现。认为，几丁糖阿霉素缓释药粒用于骨巨细胞瘤刮除术后是安全、有效的。
In order to observe the curative effect and general reaction of locally used adriamycin (ADM)loaded chitosan drug delivery system on giant cell tumor of bone after curettage. The cavities of 4 cases of giant cell tumor after curettage were filled with ADMloaded chitosan drug delivery system with 4 times the dosage usually used for intravenous application. After operation, the concentration of ADM in plasma on the 1st, 2nd and 5th day, and the functions of liver and kidney on the 1st week, 1st month and 6th month were all investigated. The results were that the concentration of ADM in plasma was (143.05±27.55) ng/ml, (52.17±11.28) ng/ml and (4.25±3.07) ng/ml respectively, and the functions of liver and kidney were all normal in 6 months. After a followup of 7～19 months, no local or general reactions were observed and Xray showed no recurrence. Therefore, it was concluded that the locally used ADMloaded chitosan delivery system was safe and effective in treatment of giant cell tumor of bone after curettage.
出处
《中国修复重建外科杂志》
CAS
CSCD
1998年第5期280-282,共3页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金
关键词
骨肿瘤
骨巨细胞瘤
药物疗法
几丁糖
阿霉素
Giant cell tumor of bone Chitosan Programmedrelease Local chemotherapy
