摘要
为探索骨肉瘤与ＨＬＡⅠ类抗原关联的内在机制，采用聚合酶链反应／顺序特异的寡核苷酸探针方法，对２２例骨肉瘤和４８例正常组织对照进行ＨＬＡＤＰＢ１等位基因检测，结果显示，作为ＨＬＡⅡ类抗原的ＤＰＢ１等位基因与骨肉瘤无相关性。
In order to explore the association between human leucocyte antigen (HLA) and osteosarcoma,a polymerase chain reaction technique and sequence specific oligonucleotide probes were used to study the distribution of HLA-DPB1 alleles in osteosarcoma.Twenty two cases of osteosarcoma and forty eight normal controls from Shanghai area were assay.The results show that the HLA class Ⅱ gene DPB1 was not correlated with osteosarcoma.It suggests that HLA class Ⅰ antigen may play a role in the pathogenesis of osteosarcoma.
出处
《实用癌症杂志》
1998年第3期190-192,共3页
The Practical Journal of Cancer
基金
国家自然科学基金
