摘要
目的：报告Ⅲ期乳腺癌术前联合化疗后的作用。材料和方法：从1982年1月至1992年1月术前以5－FU、CTX、MTX、VCR和强的松联合化疗Ⅲ期乳腺癌56例，化疗后再行手术及放化疗。结果：术前化疗后原发肿瘤明显变小，光镜下见肿瘤组织明显变性、坏死、炎细胞浸润，肿瘤区域内见血管内皮增生、管壁增厚、透明变性和血管闭塞，癌巢间胶原纤维增生及纤维化改变。其5年生存率为70．8％。同期未采用术前化疗Ⅲ期乳腺癌60例，5年生存率为36．6％。二者有明显差异（P<0．01）。结论：术前化疗对改善Ⅲ期乳腺癌的疗效、提高5年生存率具有明显作用。
: Objective To evaluate the treatment results in stage Ⅲ breast cancer by preoperative(neoadjuvant) chemotherapy. Materials and Mothods Fifty-six evaluable patients with stage Ⅲ breastcancer were treated with preoperative chemotherapy between 1982-1992. All patients received combinedchemotherapy with 5-fluorouracil, cyclophosphamide, methotrexate, vincristine and cortisone initiallyand followed by radical mastectomy 9 radiation and chemotherapy. Results After chemotherapy, the dis-tinctive histologic features were (1) obvious necrosis in cancer tissue surrounded by infiltration of inflam-matory cells, (2) vascular endothelial proliferation, marked thickning of the blood vessel wall andhyalinization or occlusion of the lumen in the turner region, (3) abundant fibrous strotna or fibrosis be-tween the cancerous cells. Five-year survival rateof this grorp was 70. 8 % as compared with 36. 6% ofthe control group. Conclusion The results suggest that there was difinitive good effect in treatment ofthe stagge Ⅲ breast cancer by preoperative chemotherapy.[
出处
《中国肿瘤临床与康复》
1998年第2期55-56,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
乳腺癌
手术前
药物疗法
Breast cancer, Preoperative Chemotherapy
