摘要
目的：评价卵巢癌P-糖蛋白、P53、P185表达对近期化疗效果的影响及相互关系。方法：免疫组织化学ABC法检测49例卵巢癌P-糖蛋白、GST－π、P53、P185表达。结果：1.卵巢癌P-糖蛋白、GST－π、P53、P185表达阳性者的近期化疗有效率分别为14．3％。27．3％、41、67％、24、63％，而表达阴性者的近期化疗有效率分别为53．6％（P<O．005）、56．3％（P<0．005）、48．2％（P>0．05）、75．0％（P<0．005）。2．P-糖蛋白、P185的表达存在相关性（P＜0．05）。结论：卵巢癌P-糖蛋白、GST－π、P185的表达明显影响其近期化疗效果。P-糖蛋白、P185表达的相关性值得进一步研究。
To evaluate the response to chemotherapy and relationship on expressionfo P-GP, GST-π, P53, p185in ovarian carcinomas. methods: lmmunohistochemical technique ABC was used to detect P-GP,GST-π,P53, P185content in 49 cases of ovarian carcinomas. results: 1. The response rates to chemotherapy of patients with positive stainingof P-GP, GST-π, P53, p185 were 14% 、27. 3%、 41. 7%、 24. 3 % respectively: but thoserates of patients with negative staining were 53. 6% (P<0. 005)、 56. 3% (P<0. 005)、48. 2% (P< 0. 05)、 75. 0% (P< 0. 005) respectively. 2. There was a close correlation between expression of P-GP and P185 (P< 0.05). conclusions: Expression of P GP,GST-π,p53and P185 affect the recent results of chemotherapy obviously in ovarian carcinomas.There was a researched value in depth on relationship between expression of P-GP andP185.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1998年第4期254-256,共3页
Cancer Research on Prevention and Treatment
