摘要
目的:观察阿卡波糖合用荷丹片降低餐后血糖、改善胰岛素敏感性的作用。方法:选择106例单纯餐后高血糖的老年患者,分为单用阿卡波糖组(对照组)53例,和荷丹片合用阿卡波糖组(观察组)53例,治疗2个月后分别观察两组的餐后血糖(2 h PG)、血脂、体重指数、以及胰岛素抵抗指数和不良反应等指标的变化。结果:观察组2 h PG、BM I、胆固醇(CH)和低密度脂蛋白(LDL-C)、甘油三脂(TG)较对照组改善明显(P<0.05)。胰岛素抵指数两组均有明显改善(P<0.05),且观察组与对照组比较差异有显著性(P<0.01)。观察组不良反应明显比对照组减少。结论:阿卡波糖与荷丹片合用,不仅可改善餐后高血糖状态,而且明显增强胰岛素敏感性,对血脂、体重指数等也有明显的改善作用,两药合用后,阿卡波糖的不良反应明显减少。
Objective：To observe the effect of combination therapy of acarbose and hedan table in improving senile postprandial hyperglycemia and insulin sensitivity. Methods ：106 patients with simple postprandial hyperglycemia were divided into the control group and the treated group,53 in each group,who were treated with acarbose alone and the combination therapy respectively for 2 months, and the changes on 2 hrs postprandial glucose （2hPG）, blood lipid, body mass index （BMI） ,insulin functional index as well as the adverse reaction of acarbose in the two groups were observed. Results ： After treatment, the levels of 2 hPG, BMI, total cholesterol and lowdensity lipoprotein - cholesterol, Triglyceride （TG） were inproved in the treated groups more significantly than those in the control group （P 〈0. 01 ）. Insulin resistance were improved in the two group （P 〈0. 05）. Moreover,the adverse reactions were less in the treated group than in the control group. Conclusion：The combination therapy of acarbose and Hedan Table could not only improve the postprandial hyperglycemia, but also markedly increase the insulin sensitivity, and shows obvious improving effect on parameters of blood lipid, BMI. The adverse reaction coule be evidently reduced, by combined use with hedan table.
出处
《中华中医药学刊》
CAS
2009年第8期1791-1792,共2页
Chinese Archives of Traditional Chinese Medicine
关键词
阿卡波糖
荷丹片
餐后高血糖
胰岛素敏感性
acarbose
hedan table
postprandial hyperglycemia
insulin sensitivity
