摘要
为了研究消化系肿瘤患者围手术期的免疫状态，应用流式细胞仪对８０例消化系统瘤患者手术前后Ｔ细胞表面３种细胞表型进行了监测，并与良性病变患者进行了对比分析。发现消化系肿瘤患者术前低于对照组（Ｐ＜０．０５），ＣＤ３＋／ＨＬＡ－ＤＲ＋与对照组相同；术后ＣＤ１６、ＣＤ６９、ＣＤ３＋／ＨＬＡ－ＤＲ＋均增高（Ｐ＜０．０５），活化Ｔ细胞ＣＤ３＋／ＨＬＡ－ＤＲ＋明显高于对照组（Ｐ＜０．０１）。提示消化系肿瘤患者术前免疫功能低下，术后活化Ｔ细胞明显增多，表明切除肿瘤有益于增强机体抗瘤能力，提高患者的免疫功能活性。
To evaluate the perioperative immune state of patients with gastrointestinal cnacer,three surface markers of T cell phenotypes were measured with flow cytometry in 80 cases before and after operation.The data was compared with that in the controls with benign disease.The results showed that before operation,CD16,CD69 were significantly lower in cancer patients than those in controls( P <0.05),and CD3 +/HLA DR + didn't show significant difference between the cancer patients and the controls.Postoperatively,CD16,CD69 and CD3 +/HLA DR + significantly increased in cancer patients( P <0.05),and furthermore,the activated T lymphocytes CD3 +/HLA DR + were much higher in cancer patients than those in controls( P <0.01).It is suggested that the immunity of gastrointestinal cancer patients was depressed and the removal of the tumor may be beneficial to improve the immunal function and enhance anticancer ability in patients.This suggests that reduction of tumor bruden by operation be necessary.
出处
《实用肿瘤杂志》
CAS
北大核心
1998年第4期211-213,共3页
Journal of Practical Oncology
关键词
消化系肿瘤
T细胞
手术前
CD16
手术后
gastrointestinal neoplasm/surgery T lmphocytes preoperative peried postoperative period
