摘要
目的：探讨大剂量卡铂化疗的安全性。方法：对６例接受大剂量卡铂并自体骨髓移植（ＡＢＭＴ）治疗的肺癌患者化疗期的药物毒性进行了观查。卡铂总剂量从５６０～１３７５ｍｇ／ｍ２，按预定方案分次静滴。５例加用ＶＰ－１６３００ｍｇ，１例并用ＭＭＣ６ｍｇ和ＶＣＲ２ｍｇ。结果：主要毒性反应为白细胞总数、中性粒细胞、血小板减少和脱发（ＷＨＯ毒性反应Ⅲ～Ⅳ级）其次是贫血、皮肤粘膜出血、呕吐和可逆性肝功能损害。其中口腔粘膜溃疡及轻度发烧各２例，一过性蛋白尿、室上性心动过速和便秘各１例，尿素氮和肌酐未见升高；全部患者骨髓均获解救，从自体骨髓回输到骨髓造血功能重建成功平均２６．６７（１７～３２）ｄ。结论：大剂量卡铂并ＡＢＭＴ治疗肺癌，在我们所使用的剂量范围内。
Objective:To investigate the toxicity of the large dose carboplatin.Methods:6 patients suffered from lung cancer were treated with high dose carboplatin with autologous bone marrow transplantation. the total doses of carboplatin ranged from 560 to 1375 mg/m2, and VP16 300 mg in 5 patients and MMC 6 mg VCR 2 mg in 1 patient were added to the regements. Results:The mainly toxic reactions were leukopenia、neutropenia、thrombocytopenia and hair loss (WHO grade Ⅲ￣Ⅳ)followed by anemia、bleeding、vomiting and reversible hepatoxicity. Mucous membrane ulceration and moderate fever were observed in each 2 patients; there were proteinuria、superior ventricular tachycardia and constipation in each 1 patient; BUN and Cr were normal The bone marrow of all patients was rescued successfully, and the everage time of recovery was 26.67(range 17 to 32)days from its reinfusion to reconstruction of hemopositic function.Conclusion:Treating lung cancer with high dose carboplantin with ABMT was safe in this dose range we taked.
出处
《军医进修学院学报》
CAS
1998年第3期213-215,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
卡铂
药物毒性
骨髓移植
肺肿瘤
carboplatin
drug toxicity
bone marrow transplantation
lung neoplasms
