摘要
目的:探讨糖调节正常代谢综合征患者的胰岛素抵抗及炎性因子的改变。方法:将62例研究对象分为时照组和糖调节正常代谢综合征(MS)组。所有患者均进行空腹血清胰岛素水平(FINS)、超敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)等检测并比较分析。结果:MS组的FINS、hs-CRP和TNF-α均较对照组显著增高,胰岛素敏感指数显著降低。简单相关分析显示hs-CRP和TNF-α与腰围、TG、SBP、FINS均呈显著正相关,与HDL-C、DBP等则无明显相关。多元逐步回归分析显示TNF-α和hs-CRP值与FINS水平间均有线性回归关系,而与腰围、TG、SBP等则均无线性回归关系。结论:糖调节正常代谢综合征患者,同样存在着胰岛索抵抗及炎性因子的改变,且其炎性程度与胰岛素抵抗密切相关。
Objective：To explore the changes of insulin resistance and inflammatory factors in normal glucose regulating patients with metabolic syndrome. Methods： 56 objects of study were divided into two groups： normal control - group, metabolic syndrome with normal glucose regulation -group （MS - group）. FINS, High sensitivity C - reactive protein（ hs - CRP） and Tumor necrosis factor - alpha（ TNF -α） were detected in 56 objects of study, then to analyze the data. Results： Compared with the normal control group, FINS, hs - CRP, TNF - α were significantly increased in MS -group, but Insulin sensitivity index（ISI） was obviously decreased in MS - group. Simple linear correlation analysis showed that there were obviously positive correlation between hs - CRP, TNF-α and Waist circumference, TG,SBP and FINS. Stepwise regression analysis showed that hs -CRP,TNF-ix were significantly related to FINS;but there were not significant correlation between hs - CRP,TNF - α and Waist circumference,TG or SBP. Conclusion： There were obvious changes of insulin resistance and inflammatory factors in normal glucose regulation pa tients with metabolic syndrome. Meanwhile the degree of inflammatory was closely correlated with insulin resistance.
关键词
代谢综合征
胰岛素抵抗
超敏C反应蛋白
肿瘤坏死因子Α
Metabolic syndrome
Insulin resistance
High sensitivity C -reactive protein
Tumor necrosis factor - alpha
