摘要
目的:探讨中国南方汉族人群中雌激素受体α(ERα)基因xbaI酶切多态性与冠心病危险因素的相关性。方法:应用聚合酶链反应-限制片断长度多态性(PCR-RFLP)分析的方法,检测236例冠心病(CAD)患者和117例对照组的ER基因型,并比较其与相关临床指标的关系。结果:ERα基因XbaI多态性存在XX、Xx、xx三种基因型,ERα、xbaI基因多态性与CAD患者年龄、性别、高血压、糖尿病、吸烟等CAD的经典危险因素及胆固醇、低密度脂蛋白、高密度脂蛋白、甘油三脂等生化因素含量无关(P>0.05)。结论:在中国南方汉族人群中存在着ERα、XbaI基因多态性,与冠心病的危险因素无相关性。
Objective：To detect the association of estrogen receptor α gene （ ER - α ） Xba I polymorphisms with risk factors of coronary artery disease （ CAD ） in South Chinese Han nationalities. Method：By using PCR- RFLP analysis method, ER gene types in CAD patients and healthy controls were detected, and the association of gene types with correlation indexes were analyzed. Results：All the three genotypes include XX,Xx,xx were detected, ER - α Xba Ⅰ polymorphisms were not associated with classic risk factors of CAD such as age, gender, hypertension, diabetes mellitus, smok- ing, cholesterol, LDL - C, HDL - C, TG. Conclusions： The XbaI polymorphisms of ERα gene were detectable, and the ER - αgene XbaⅠ polymorphisms werenot associated with CAD risk factors in south Chinese Han nationality.
基金
广东省科技计划项目(2006836007005)
关键词
雌激素受体
冠心病
基因多态性
危险因素
Estrogen receptor
Coronary artery disease （ CAD ）
Gene polymorphism
Risk factor
