摘要
以酒石酸酯为手性助剂，以２萘甲醚为原料，经溴化、酰化、缩合、不对称α溴化、水解、重排及脱溴选择性合成（Ｓ）萘普生．
A highly enantioselective synthesis of (S)Naproxen,based on the use of tartaric acid ester as chiral auxiliary, from 2methoxynaphthene via bromination,acylation,condensation,diastereoselective αbromination,hydrolysis,rearrangement and debromination was described in this paper.
出处
《沈阳药科大学学报》
CAS
CSCD
1998年第3期193-195,共3页
Journal of Shenyang Pharmaceutical University
关键词
酒石酸酯
手性助剂
不对称合成
萘普生
tartaric acid ester
chiral auxiliary
asymmetric synthesis
(S)Naproxen
