摘要
目的观察妊娠期抗甲状腺过氧化物酶抗体(TPOAb)的阳性率,为评估孕妇甲状腺功能减退症(甲减)和甲减对妊娠及其结局的影响提供理论依据。方法应用化学发光法(CIA)测定2008年3月至12月间,在山西医科大学第一医院妇产科筛查的149名妊娠女性血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平、TPOAb。结果TPOAb阳性率甲减组比亚临床甲减组高,既往有甲状腺病史组比无甲状腺病史组高,差异有统计学意义(P<0.01)。结论妊娠期TPOAb阳性率与甲状腺功能变化有密切关系,TPOAb检测在妊娠期有着重要意义。
Objective To evaluate hypothyroidism and subclinical hypothyroidism on the pregnancy and its outcome,we study the positive rate of TPOAb during pregnancy. Methods With high-sensitive chemical irradiance assay（CIA） technique, we analyzed the concentrations of thyroid stimulating hormone（TSH）, free triiodothyroxine（FT3 ）,free thyroxine （FT4） and TPOAb in 149 pregnant women who visited and delivered in the First Hospital of Shanxi Province from March 2008 to December 2008. Results The positive rate of TPOAb in hypothyroidism group is significantly higher than that of subclinical hypothyroidism group as well as the patients with a past history of thyroid disease to those without it（ P 〈0.01）. Conclusion The positive rate of TPOAb is closelyrelated to the change of thyroid function and it is very important to have a test during pregnancy.
基金
山西省回国留学人员科研资助(91)
