摘要
为探索血清中氧化型低密度脂蛋白（氧化型LDL）自身抗体与冠心病及血脂的关系，采用酶联免疫吸附试验，检测105名健康体检者和92例冠心病患者血清中氧化型LDL自身抗体的含量，并与不同血脂水平作相关性检验。结果发现，冠心病组血清氧化型LDL自身抗体的含量高于正常对照组（P＜0．01），且高脂血症患者氧化型LDL自身抗体阳性率高于正常者；45岁以上者阳性年高于45岁以下者，自身抗体滴度与甘油三酯和总胆固醇水平呈正相关。自身抗体的检测反映了氧化型LDL在体内的氧化情况，其含量可能受胆固醇含量等影响脂质氧化因素的影响。
Aim: This study evaluated the relation between autoantibody against oxidized low density lipoprotein (ox-LDL) and serum lipids in patients with coronary heart disease (CHD).Methods: The titre of autoantibodies aganist oxLDL and lipid levels in samples of 92 CHD and 105 healthy controls were measured using the enzymelinked immunosorbent assay techinque.Results: The experiment showed that patients withCHD had significant higher levels of autoantibodies than control subjects in regard to anti-ox-LDL IgG(0.45±0. 13 versus 0. 35± 0.09, P<0. 01 ), and the positive rate of autoantibodies was predominant in the subjects with hypertriglyceridemia, hypercholesterolemia,higher LDL cholesterol, and elderly people (≥45), the differences were significant. The titre of autoantibodies against ox-LDL was correlated with total cholesterol (TC) and triglycerides (TG ), Their correlation coefficients were 0. 360 and 0. 408, these were also significantly different.Conclusions: The presence and increase in autoantibodies titers in patients with CHD could be considered a reliable sign of an increased LDL oxidation in vivo,and the titre of autoantibodies could be influenced by the degree of hypercholesterolemia or other factors which influence lipid peroxidation.
出处
《中国动脉硬化杂志》
CAS
CSCD
1998年第2期95-97,共3页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金!39270291
浙江省自然科学基金!392014
关键词
冠心病
脂蛋白
低密度
自身抗体
Coronary heart disease
Lipoprotein, low density
Autoantibody
