摘要
目的:观察新生儿惊厥持续状态应用咪达唑仑与苯巴比妥钠的疗效。方法:72例惊厥持续新生儿,随机分为治疗组及对照组各36例,治疗组予咪达唑仑负荷量0.1～0.3mg/(kg.次)静脉推注,再予静脉维持量1.0μg/(kg.min)维持,如果惊厥不能控制,则每15min增加维持剂量1.0μg/(kg.min)直到惊厥停止。对照组予苯巴比妥钠10mg/(kg.次),如果惊厥不能控制,30min可以再予10mg/(kg.次)。注入药物1h内惊厥停止为有效,1h后惊厥未停止为无效,对比观察两组控制惊厥的时间。结果:治疗组有效率为83.0%,对照组有效率为67.0%;治疗组用药控制时间(22±15.2)min,对照组用药控制时间(31±16.3)min,治疗组疗效明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论:咪达唑仑是治疗新生儿惊厥持续状态快速、有效的药物。
Objective：To study the efficacy of midazolam and sodium phenobarbital in treating neonatal convulsiens status epileptieus. Methods： Study comprised 72 newborns with neonatal convulsiens status epileptieus, they were divided randomly into 2 groups with 36 cases in each. The treatment group was, firstly, given a charge of midazolam of 0.1 - 0.3 mg/kg once. After a quarter of an hour, a maintenance dose of 1.0 μg/（kg ·min） was added, and then a dose of 1.0 μg（kg · min） was added every 15 minutes until the convulsion stopped. As a contol, 36 cases were given the sodium phenobarbital 10 mg/kg once, after half of an hour, a dose of 10 mg/kg was added if the convulsion can＇t stopped. The time of convulsiens status epileptieuss control were compared between the two groups. Results： The treatment efficiency of treatment group was 83.0%, and was 67.0% of control group. The convulsions control time was （22 ± 15.2） minutes in treatment group, and was （31 ± 16.3） minutes in control group. Efficacy of the treatment group was better than the control group （P 〈0.05）. Conclusions： Midazolam is fast and effective in treating neonatal connvulsiens status epileptieus.
出处
《儿科药学杂志》
CAS
2009年第4期27-28,共2页
Journal of Pediatric Pharmacy
关键词
咪达唑仑
苯巴比妥钠
新生儿
惊厥持续状态
Midazolam
Sodium phenobarbital
Neonatal
Convulsiens status epileptieus
