摘要
目的:评价大剂量静脉丙种球蛋白联合地塞米松、单独大剂量静脉丙种球蛋白及单独大剂量地塞米松三种方法治疗急重型儿童特发性血小板减少性紫癜(ITP)的疗效。方法:对入院时PLT≤25×109/L、出血倾向明显的66例ITP患儿分成三组,每组22例。联合组静脉滴注丙种球蛋白400mg/(kg.d),连用5d,同时静脉滴注地塞米松1.5mg/(kg.d),连用5d,于治疗第6d起口服泼尼松2mg/(kg.d);丙种球蛋白组仅给予静脉滴注丙种球蛋白400mg/(kg.d);地塞米松组静脉滴注地塞米松1.5mg/(kg.d),连用5d,于治疗第6d起口服泼尼松2mg/(kg.d)。结果:联合组、丙种球蛋白组、地塞米松组使PLT升至50×109/L以上的时间分别为(2.1±0.6)d、(3.1±0.6)d、(4.0±0.8)d,组间两两相比差异均有统计学意义(P<0.05);PLT100×109/L以上的时间分别为(4.4±1.0)d、(5.6±1.3)d、(7.1±1.1)d,组间两两相比差异均有统计学意义(P<0.05);PLT达峰值的时间分别为(10.1±1.2)d、(11.2±1.3)d、(13.5±1.9)d,组间两两相比差异均有统计学意义(P<0.05);PLT的峰值分别为(267±85)×109/L、(253±74)×109/L、(223±72)×109/L,组间两两相比差异均无统计学意义(P>0.05)。结论:大剂量静脉丙种球蛋白联合地塞米松静脉滴注治疗急重型儿童ITP比单独使用其中任一种药物升高血小板的作用更迅速。
Objective： To evaluate the effectiveness of high-dose immunoglobulin combined with dexamethasone, high-dose immunoglobulin, high-dose dexamethasoneand in children with acute severe idiopathic thrombocytopenlc purpura （ITP）. Methods： Sixty-six patients hospitalized with PLT≤25 × 10^9/L and phanero-tendency of hemorrhage were randomly divided into three groups （ every group n = 22）. The group of combined treatment was intravenous-dripped with immunoglobulin 400 mg/（kg ·d） for five days and 1.5 mg/（ kg · d） of dexamethasone for five days, and after the five days was orally administrated with 2 mg/（ kg · d） of prednisolone. The group of immunoglobulin was intravenously dripped with 400 mg/（ kg · d） of immunoglobulJn for five days. The group of dexamethasone was intravenously dripped with 1.5 mg/（ kg · d） of dexamethasone for five days, and then orally with orednisolone 2 mg/（ kg · d）.Results： In the group of combined treatment, the group of immunoglobulin and the group of dexamethasone, the time of PLT≥50×10^9/L was （2. 1±0.6） days, （3.1±0.6） days, （4.0±0.8） days respectively, and the statistically significant differences among the three groups were found （ P 〈 0.05 ）. The time of PLT ≥ 100× 109/L was （ 4.4 ± 1.0） days, （ 5.6 ± 1.3 ） days, （ 7.1± 1.1 ） days respectively with a statistically significant difference among them （P 〈0.05）. The time of PLT up to the peak value was （ 10. 1 ± 1.2） days, （ 11.2 ± 1.3 ） days, （ 13.5 ± 1.9 ） days respectively and a statistically significant difference （ P 〈 0.05 ） was found among them. The peak value of PLT was （267±85） × 109/L, （253±74） × 109/L, （223±72） × 109/L respectively and there was no statistically significant difference found （P 〉 0. 05 ）. Conclusions： Intravenous drip of high-dose immunoglobulin combined dexamethasone is more rapidly than any medications in increasing the platelet count in children with acute severe ITP.
出处
《儿科药学杂志》
CAS
2009年第4期24-26,共3页
Journal of Pediatric Pharmacy
