摘要
目的:观察辛伐他汀与阿司匹林联用对反复短暂性脑缺血发作(TIA)患者血脂和血液流变学的影响及其疗效。方法:将51例反复TIA患者随机分为观察组(n=26,辛伐他汀与阿司匹林联用)和对照组(n=25,单用阿司匹林)。辛伐他汀20mg日一次口服,阿司匹林100mg日一次口服,治疗12周后与对照组比较疗效及血脂、血液流变学的变化。结果:观察组总有效率92.3%,与对照组比较差异有显著性(P<0.05);血脂TG、TC、LDL-C,水平下降、HDL-C水平升高,与对照组比较差异有显著性(P<0.05);同时血液流变学全血高切粘度、低切粘度、血浆粘度、纤维蛋白原明显下降,与对照组比较差异有显著性(P<0.05)。结论:辛伐他汀可能通过调节血脂水平,改善血液流变学等机制,与阿司匹林联合治疗反复短暂性脑缺血发作疗效显著。
Objective：To observe the influence and therapeutic of the patients＇ lipid and hemorheology used Simvastatin and Aspirin combination therapy transient ischemic attack.Method：Made 51 cases divided into two groups randomly, the observation group（26 cases,used Simvastatin and Aspirin）,the control group（25 cases,only used Aspirin）.Simvastatin 20mg orally Once a day, Aspirin 100mg orally Once a day, comparison between the two groups＇ lipid and hemorheology.Result：The total effective rate of the observation group was 92.3%,there were significant differences between the two groups（P〈0.05）;lipid TG, TC, LDL-C decline,HDL-C rising,while the high viscosity, Low viscosity, plasma viscosity and fibrinogen in Hemorheology decline.There were significant differences between the two groups（P〈0.05） also.Conclusion：Simvastatin can improve the hemorheology maybe through adjust lipid levels,the notable effect of Simvastatin and Aspirin combination therapy transient ischemic attack.
出处
《中国医药导刊》
2009年第7期1158-1159,共2页
Chinese Journal of Medicinal Guide
