摘要
目的探讨小剂量奥美拉唑治疗功能性消化不良(FD)的临床疗效。方法选择2005年8月～2008年10月沈阳市第四人民医院门诊收治的明确诊断的260例FD患者,其中观察组为奇数病例,采用口服小剂量奥美拉唑(10mg/d)治疗。对照组为偶数病例,采用埃索美拉唑(20mg/d)、多潘立酮(吗丁啉)(10mg/d)联合用药治疗。观察两组患者烧心、饱胀、上腹不适及嗳气等临床症状的改善程度。结果两组治疗前后,烧心、上腹痛、嗳气评分下降差异均有统计学意义(P<0.01),而饱胀分级评分下降观察组差异无统计学意义(P>0.05),对照组差异无统计学意义(P<0.05),但两组比较差异无统计学意义(P>0.05)。总缓解率观察组为79.9%,对照组为81.2%,两组比较差异无统计学意义(P>0.05)。结论小剂量奥美拉唑治疗FD疗效肯定,与埃索美拉唑、多潘立酮联合用药效果相近,且不良反应少,可作治疗FD首选用药。
Objective To investigate the clinical efficacy of treatment of low-dose omeprazole in functional dyspepsia(FD).Methods To select from August 2005 to October 2008 in Shenyang No.4 city people's hospital the clear diagnosis of out-patient treatment of 260 cases of FD patients,which is an odd number of cases the observation group,the use of oral low-dose omeprazole(10mg/d)treatment.The control group is an even number cases,the use of esomeprazole(20mg/d),domperidone(motilium)(10mg/d) combination treatment.The two groups were observed in patients with heartburn,fullness,epigastric discomfort and belching and other improvements in clinical symptoms.Results The two groups before and after treatment,heartburn,upper abdominal pain,belching score differences were statistically significant decline(P< 0.01),and satiety score classification decreased the observation group there was no significant difference(P>0.05),the control group the difference was not statistical significance(P<0.05),but the difference between the two groups was not significan(tP>0.05).Total remission rate of 79.9 percent for the observation group,the control group was 81.2%,and there was no significant difference(P>0.05)between the two groups.Conclusion Low-dose omeprazole treatment efficacy certainly FD with esomeprazole,domperidone is similar to the effect of combination therapy,and fewer adverse reactions and can be used for the treatment of choice for ED drugs.
出处
《中国现代医生》
2009年第21期60-61,63,共3页
China Modern Doctor
