摘要
随着基因技术的发展，基因修饰干细胞用于下肢缺血疾病的治疗逐渐成为可能。基因修饰能使干细胞更好应用于下肢缺血的治疗。在细胞移植前，进行细胞基因修饰，提高了细胞的存活，尤其是干细胞，且可增强细胞治疗效果，但该治疗方法目前仅限于实验阶段。本文就基因修饰骨髓间充质干细胞目前在下肢缺血疾病治疗应用方面做一综述。
With the development of gene technology,it is gradually possible and much better for genetic modification of hone marrow stem cells in treatment of hindlimb isehemia. Gene modification of cells prior to their transplantation, especially stem cells, enhances their survival and increases their function in cell therapy. But this treatment is only used for the experimental stage. Here, we review the current uses of gene-modified bone marrow stem cells in vascular disease.
出处
《国际外科学杂志》
2009年第8期538-541,共4页
International Journal of Surgery
基金
福建省科技厅基金资助省属高校项目（No.2008F5022）
关键词
基因治疗
干细胞
下肢缺血
gene therapy
stem cells
hindlimb isehemia
