摘要
目的测定原发性肾病综合征(PNS)和紫癜性肾炎(HSPN)患儿血浆中纤溶酶原(PLG)活性(PLG∶A)、血管性假血友病因子(vWF)水平、抗凝血酶Ⅲ(AT-Ⅲ)活性(AT∶A)、纤维蛋白原(FIB)的水平,并探讨其在鉴别诊断中的意义。方法取41例PNS患儿和32例HSPN患儿血浆,采用发色底物法测定PLG∶A、AT∶A,免疫比浊法测定vWF水平,磁珠凝固法测定FIB水平。结果PNS患儿血浆PLG∶A及AT∶A水平分别为(69.15±17.61)%及(58.32±26.38)%各自均低于HSPN患儿的水平,后者PLG∶A水平为(93.51±15.57)%、AT∶A水平为(123.80±26.40)%,差异有统计学意义(P<0.01);PNS患儿血浆vWF水平及FIB水平分别为(211.40±62.61)%及(5.11±0.98)g/L各自均高于HSPN患儿的水平,后者vWF水平及FIB水平分别为(119.51±46.30)%及(3.25±0.79)g/L,差异有统计学意义(P<0.01)。结论PNS患儿血浆凝血活性较HSPN患儿高,检测PLG∶A、AT∶A、vWF、FIB有助于两者的鉴别诊断。
Objective To explore the clinical significance of the levels of plasminogen activity （ PLG ： A ） , antithrombin-Ⅲ activity（ AT： A）, Von Willebrand factor（vWF） and fibrinogen（ FIB ）in the children patients with primary nephrotic syndrome（PNS） and Henoch-Schonlein purpura nephritis （HSPN）. Methods The plasma samples from 41 PNS children and 32 HSPN children were collected. PLG： A, AT： A were measured by spectrophotometry, vWF by immunoturbidimetric assay, FIB by magnetic bead clotting. Results The levels of PLG： A and AT： A in PNS children （69.15 ＋17.61）% and （58.32 ±26.38）% were significantly lower than that in the HSPN group[ （93.5 ± 15.57） and （ 123.80± 26.40） % , P 〈 0.01 ]. While the levels of vWF and FIB in PNS children[ （211.40±62.61 ） % and （ 5.11 ±0.98） g/L]were significantly higher than that in the HSPN group[ （119.5 ±46.30）% and （3.25 ±0.79）g/L,P 〈 0.01 ]. Conclusions There is hypercoagy lable state in PNS children. Determination of PLG： A, AT： A, vWF and FIB has significantly value in differential diagnosis of PNS and HSPN.
出处
《检验医学》
CAS
北大核心
2009年第7期533-535,共3页
Laboratory Medicine
