摘要
目的通过观察动脉灌注不同浓度、不同剂量脂肪乳(LE)对血流速度的影响,探讨LE作为载体的作用机制。方法以20%和30%LE进行动脉灌注,剂量分别为2ml和20ml,分为4组:A组(20%LE,2ml)、B组(20%LE,20ml)、C组(30%LE,2ml)、D组(30%LE,20ml)。用2只健康杂种犬,在DSA引导下分别置管于肝动脉、脾动脉进行灌注。统计各组从导管头端对比剂显现至脾动脉、肝动脉选定点血管显影所需的帧数,并记录造影时间。结果不同浓度和剂量的LE灌注后均可减缓血流速度,但减缓的持续时间和最大减缓速度(减缓峰值)有所不同(P<0.05)。A组约5min血流速度恢复正常,B组需5～10min,C组需20min,D组需20～30min;流速减缓峰值于A组为18帧(1.44s),B组为30帧(2.4s),C组为9帧(0.72s),D组为14帧(1.12s)。结论LE经动脉灌注后均可造成局部血流速度减缓,30%LE造成流速减缓程度比20%LE轻,但其持续时间较长。
Objective To investigate the function mechanism of lipid emulsion （LE）, used as a carrier, by observing the effect of intra-arterial infusion of LE in different concentration and dosage on blood flow velocity. Methods According to the concentration and dosage used in arterial infusion, the experiments were divided into four groups： group A （20% LE, 2 ml）, group B （20% LE, 20 ml）, group C （30% LE, 2 ml） and group D （30% LE, 20 ml）. Two healthy hybrid dogs were used for the study. Under DSA guidance, the 4 F catheter was placed in the splenic artery and in the hepatic artery respectively. DSA frames were counted in order to calculate the time that the contrast took from the catheter tip to the selected tertiary branches of the splenic or hepatic artery. Results LE infusion, regardless of its concentration level or its dosage, could reduce the blood velocity. The lasting time and the maximal peak value of the blood velocity reduction were significantly different among groups （P 〈 0.05）. The lasting time was 5 minutes, 5-10 minutes, 20 minutes and 20 - 30 minutes among group A, B, C and D, respectively. The peak value of the reduction appeared at the 18th frames （1.44 s）, 30th frames （2.4 s）, 9th frames （0.9 s） and 14th frames （1.12 s） in group A, B, C and D, respectively. Conclusion Intra-arterial infusion of LE can reduce the blood flow velocity. The lasting time of the reduction in 30% LE groups is longer than that in 20% LE groups, while the blood velocity reduction in 30% LE groups is less than that in 20% LE groups.
出处
《介入放射学杂志》
CSCD
北大核心
2009年第7期526-528,共3页
Journal of Interventional Radiology
关键词
脂肪乳
血流速度
介入放射学
实验研究
lipid emulsion
blood flow velocity
interventional radiology
experimental study
