摘要
目的研究肝得安对小鼠实验性肝损伤的保护作用。方法将60只小鼠随机分成6组(每组10只),分别是空白对照组,模型对照组和阳性药对照组、肝得安高(6g/kg)、中(3g/kg)、低(1.5g/kg)剂量组。结果肝得安可明显降低上述急性肝损伤模型小鼠血清ALT、AST活性及肝组织中MDA的含量,同时增高肝SOD的活性,且能改善肝脏病理损伤。结论肝得安对小鼠实验性肝损伤具有保护作用。
Objective To investigate the protective effect of Gandean against experimental liver injury. Methods Sixty mice were randomly divided into six groups（ n = 10） ：normal control group ,model control group, positive control group and three treatment groups with Gandean 6,3,1.5 g/kg. The activities of serum alanine aminotransferase （ALT）, aspar tate aminotransferase （AST） and the activity of liver superoxide dismutase （SOD） ,malondialdehyde（MDA） were determined in injured liver induced by carbon tetrachl - oride （ CCl4 ）, D - Galactosamine （ D - Gal）, alcohol or acetaminophen （ AP）, and the pathological change of liver tissue was observed. Results The activities of ALT , AST in serum and the content of liver MDA were significantly lowered, and the activity of liver SOD was increased obviously in liver induced by CCl4, D - Gal, alcohol or AP after Gandean was given orally. Histological results displayed that Gandean improved liver injury. Conclusion Gandean has protective effect against experimental liver injury.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第7期1759-1761,共3页
Lishizhen Medicine and Materia Medica Research
