期刊文献+

吉西他滨联合顺铂治疗晚期非小细胞肺癌临床观察 被引量:3

暂未订购
导出
摘要 目的:观察吉西他滨联合顺铂(GP)治疗晚期非小细胞肺癌的有效性和毒性反应。方法:应用GP治疗晚期NSCLC患者38例,并与采用环磷酰胺和阿霉素联合顺铂(CAP)治疗的晚期NSCLC患者32例进行对比分析。结果:总有效率:GP组为36.8%,CAP组为15.6%,两组差异有统计学意义(P<0.05)。血液学毒性和胃肠道毒性,两组差异无统计学意义(P>0.05)。结论:吉西他滨联合顺铂治疗晚期NSCLC有较好疗效,其毒副作用易于防治,安全性及耐受性较好,尤为适合在中老年肺癌患者应用。
出处 《交通医学》 2009年第2期166-167,共2页 Medical Journal of Communications
  • 相关文献

参考文献3

二级参考文献21

  • 1Mok TS Zee B Chan AT et al.A phase Ⅱ study of gemcitabine plus oral etoposide in the treatment of patients with advanced non-small cell lung carcinoma [J].Cancer,2000,89(3):543-550.
  • 2Greenlee RT, Murray T, Bolden S, et al. Cancer Statistics [J]. CA Cancer J Clin, 2000,50 (1):7-33.
  • 3Feld R, Abratt R, Graziano S, et al. Pretreatment minimal staging and prognostic factors for non small cell hung cancer [J]. Lung Cancer,1997,17(Suppl 1 ):S3-10.
  • 4Graziano SL, Kern JA, Herndon JE, et al . Analysis of neuroendcrine markersHER2 and CEA before and after chemotherapy in patients with stage Ⅲ A non small cell lung cancer: a Cancer and Leukemia Group B study[J]. Lung Cancer, 1997,21 (3) : 203-211.
  • 5Rafael R , Mark G, Paul G. Adervances in the treatment of non-small cell lung cancer: molecular markers take the stage [J]. Sem Oncol, 2001,1 (28)28-34.
  • 6Cullen MH, Billingham, LJ, Woodroffe CM, et al. Mitomycin, ifosfarnide, and cisplatin in unresectable non-small cell lung cancer:effects on survival and quality of life[J]. J Clin Oncol, 1999,17(10):3188-3194.
  • 7Anderson H, Hopwood P, Stephens RJ, et al. Gemcitabine plus best supportive care (BSC) vs BSC in inoperable non-small cell lung cancer-a randomized trial with quality of life as the primary outcome. UK NSCLC Gemcitabine Group [J]. Anticancer Res, 2000, 20 (3B):2229-2233.
  • 8Wozniak A J, Crowley JJ, Ba Lcerzak SP, et al. Randomized trial comparing cixplatin with a splatin plus vinorelbine in the tzeatment of advanced non-small-cell lung cancer:a Southwest Oncology Group Study [J]. J Clin Oncol, 1998,16(7):2459-2465.
  • 9Sandier A,Nemunaitis J,Denham C, et al. Phase Ⅲ trial of gemcitabine plus cisplatin vesus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer [J]. J Clin Oncol,2000, 18(1) : 122-130.
  • 10von Pawel J, von Roemeling R, Gatzemeier U, et al. Tirapazarmine plus cisplatin versus cisplatin in advanced non small cell lung cancer:A report of the international CATAPULT study group . Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors[J]. J Ctin Oncol, 2000, 18(6):1351-1359.

共引文献182

同被引文献19

  • 1冷嘉兴,徐建忠,孙毅,徐珍,孔颖泽.吉西他滨联合顺铂治疗晚期非小细胞肺癌的临床研究[J].现代肿瘤医学,2005,13(3):393-394. 被引量:6
  • 2周彩存,钟文昭.吉西他滨联合铂类与其他含铂方案治疗晚期非小细胞肺癌的疗效比较:关于生存结果的荟萃分析[J].循证医学,2005,5(3):143-146. 被引量:70
  • 3李红梅,高雅苓.含顺铂的三种化疗方案治疗非小细胞肺癌的临床比较[J].肿瘤防治研究,2006,33(9):670-672. 被引量:7
  • 4Ire Chevalier T.Management of early- stage non- small- cell lung cancer (NSCLC)[J]. Eur J Cancer, 2011,47 (Suppl 3):S292-293. doi: 10.1016/S0959-8049(11)70176-9.
  • 5Agarwal N, Apolo AB, Tsao CK, et al. Phase Ⅰb/Ⅱ Trial of Gem- citabine, Cisplatin, and Lenalidomide as First-l.ine Therapy in Pa- tients With Metastatic Urothelial Carcinoma[J]. Oncologist, 2014 Jul 22. pii: theoncologist. 2014-0153. [Epub ahead of print].
  • 6Galsky MD, Posner M, Holcombe RF, et al. Phase lb study of dovi- tinib in combination with gemcitabine plus eisplatin of gemcitabine plus earboplatin in patients with advanced solid tumors[J]. Cancer Chemother Pharmacol, 2014 Jul 15. [Epub ahead of print].
  • 7Aspe JR, Diaz Osterman C J, Jutzy JM, et al. Enhancement of Gem- citabine sensitivity in pancreatic adenocarcinoma by novel exo- some-mediated delivery of the Survivin-T34A mutant[J]. J Extra- cell Vesicles, 2014 Feb 17;3. doi: 10.3402/jev.v3.23244. e.
  • 8Collec- tion 2014. Keskin S, Tas F. Ekenel M, et al. Biweekly triplet chemotherapy with gemcitabine; cisplatin and vinorelbine for advanced chemother- apy narve non- small cell lung cancer[J]. Tumori,2013,99(4):463- 468. doi: 10.1700/1361.15095.
  • 9Gansukh T, Donizy P, Halon A, et al. in Vitro Analysis of the Rela- tionships Between Metallothionein Expression and Cisplatin Sensi- tivity of Non-small Cellular Lung Cancer Cells[J]. Anticancer Res, 2013,33( 12):5255-5260.
  • 10Chang PY, Dai MS, Ho CL, et al. Administration of gemcitabine and cisplatin in cancer patients with renal failure under hemodialysis[J]. J BUON ,2013,18(4):1058-1061.

引证文献3

二级引证文献14

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部