期刊文献+

大鼠局灶性脑缺血再灌注后Caspase-9蛋白的表达 被引量:1

暂未订购
导出
摘要 目的研究Caspase-9蛋白在大鼠脑缺血再灌注损伤过程中表达水平的动态变化。方法建立大鼠局灶性脑缺血再灌注模型,应用HE染色和免疫组织化学方法观察神经细胞死亡情况,再灌注6h、12h、24h后缺血皮层Caspase-9蛋白表达。结果与假手术组比较Caspase-9蛋白表达在各手术组明显升高,并随着缺血再灌注时间的延长Caspase-9表达逐渐升高,于再灌注24h到达最高(P<0.01)。结论Caspase-9蛋白参与了脑缺血再灌注损伤过程。
出处 《中西医结合心脑血管病杂志》 2009年第7期803-804,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
  • 相关文献

参考文献1

二级参考文献1

共引文献42

同被引文献18

  • 1Downward J. PI 3-kinase,Akt and cell survival[J].{H}Seminars in Cell and Developmental Biology,2004,(2):177-182.
  • 2Wang J,Zhao H,Mao-Ying QL. Electroacupuncture downregulates TLR2/4 and pro-inflammatory cytokine expression after surgical trauma stress without adrenal glands involvement[J].{H}Brain Research Bulletin,2009,(1-2):89-94.
  • 3Manning BD,Cantley LC. AKT/PKB signaling:navigating downstream[J].{H}CELL,2007,(7):1261-1274.
  • 4Mullonkal C J,Toledo-Pereyra LH. Akt in ischemia and reperfusion[J].{H}Journal of Investigative Surgery,2007,(3):195-203.
  • 5Xi HJ,Zhang TH,Tao T. Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression[J].{H}Brain Research,2011,(1410):24-32.
  • 6Zhang GC,Fu WB,Xu NG. Meta analysis of the curative effect of acupuncture on post-stroke depression[J].{H}Journal of Traditional Chinese Medicine,2012,(1):6-11.
  • 7Longa EZ,Weinstein PR,Carlson S. Reversible middle cerebral artery occlusion without craniectomy in rats[J].{H}STROKE,1989,(1):84-91.
  • 8Kriz J,Lalancette-Hébert M. Inflammation,plasticity and real-time imaging after cerebral ischemia[J].{H}Acta Neuropathologica,2009,(5):497-509.
  • 9Slack JL,Schooley K,Bonnert TP. Identification of two major sites in the type I interleukin-l receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways[J].{H}Journal of Biological Chemistry,2000,(7):4670-4678.
  • 10J(o)rgensen HS,Nakayama H,Pedersen PM. Epidemiology of stroke-related disability[J].{H}CLINICS IN GERIATRIC MEDICINE,1999,(4):785-799.

引证文献1

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部