摘要
选择性垂体甲状腺激素抵抗是甲状腺抵抗综合征中的一种少见类型，为一种常染色体显性遗传性疾病。主要由于甲状腺激素受体β亚基基因突变所致。它的临床特征为轻度甲状腺功能亢进，实验室检查提示游离L、游离T4升高的同时伴有促甲状腺激素的不适当分泌。治疗可选用三碘甲状腺醋酸、右旋L、溴隐亭等，目前尚无根治方法。
Pituitary resistance to thyroid hormone（PRTH） is a kind of autosomal dominant hereditary disease. It is mainly caused by the mutations of the thyroid hormone receptor beta gene. The feature of laboratory is elevated serum free thyroxine （ FT4 ） and free triiodothyronine （ FT3 ） with inappropriate TSH. 3,5,3 ＇- triiodothyroacetic acid（ TRIAC）, D-T4, bromocriptine have been used in the therapy of PRTH, however,no radical cure has been found now.
出处
《国际内分泌代谢杂志》
2009年第4期271-273,共3页
International Journal of Endocrinology and Metabolism
关键词
垂体甲状腺激素抵抗
基因突变
Β亚单位
三碘甲状腺醋酸
Pituitary resistance to thyroid hormone
Gene mutation
Beta subunit
3,5,3＇-triiodothyroaeetic acid
