摘要
本文观察了多潘立酮、胃复安及消呕宁对(60)~CO γ线7Gy 照射狗照后早期呕吐的预防与治疗作用。结果表明,多潘立酮预防用药的止吐作用最好,对照狗82%(9/11)产生呕吐,多潘立酮预防用药组5只狗全部无呕吐出现。胃复安预防用药可使照射动物呕吐发生率减少42%,呕吐次数及呕吐持续时间亦较对照有所减少与缩短。其它四个给药组的呕吐发生率与对照组相似,但呕吐次数及呕吐持续时间有较对照组减少与缩短的趋势。
Domperidone,metoclopramide and sulpiride were examined for their protective and the- rapeutic effects against the emesis within 6 hours after 7Gy ^(60)Co γ-irradiation in 40 dogs. The incidence of emesis occurred in control group was 82%(9/11).All five dogs protected with domperidone could prevent radiation-induced emesis.The metoclopramide could eliminate radiation induced emesis in three of five dogs too.In other four groups (domperidone the- rapeutic,metoclopramide therapeutic,sulpiride protective or therapeutic) the incidence of eme- sis was the same as in control,but the episodes of vomiting and duration between the onset and last episodes were decreased.
出处
《军事医学科学院院刊》
CSCD
北大核心
1990年第4期248-251,共4页
Bulletin of the Academy of Military Medical Sciences
关键词
辐射呕吐
多潘立酮
胃复安
消呕宁
radioemesis
domperidone
metoclopramide
sulpiride
